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Q74084 (Q74084_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:gag EMBL BAA12996.1
OrganismHuman immunodeficiency virus 1 EMBL BAA12996.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity. SAAS SAAS012344

Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity. SAAS SAAS012344

Subcellular location

Virion By similarity SAAS SAAS010999.

Post-translational modification

Specific enzymatic cleavages by the viral protease yield mature proteins By similarity. RuleBase RU004487

Sequence similarities

Contains 2 CCHC-type zinc fingers.

Contains CCHC-type zinc fingers. SAAS SAAS001878

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding3921Zinc 1 PDB 1BJ6
Metal binding3951Zinc 1 PDB 1BJ6
Metal binding4001Zinc 1; via tele nitrogen PDB 1BJ6
Metal binding4051Zinc 1 PDB 1BJ6
Metal binding4131Zinc 2 PDB 1BJ6
Metal binding4161Zinc 2 PDB 1BJ6
Metal binding4211Zinc 2; via tele nitrogen PDB 1BJ6
Metal binding4261Zinc 2 PDB 1BJ6

Sequences

Sequence LengthMass (Da)Tools
Q74084 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AB5CC38B0414E085

FASTA51257,267
        10         20         30         40         50         60 
MGARASVLSG GKLDRWEKIR LRPGGKKKYK LKHIVWASRE LERFAVNPGL LETSEGCRQI 

        70         80         90        100        110        120 
LGQLQPSLQT GSEERRSLYN TVATLYCVHQ RIEIKDTKEA LDKIEEEQNK SKKKAQQAAA 

       130        140        150        160        170        180 
NTGHSSQVSQ NYPIVQNIQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT 

       190        200        210        220        230        240 
PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRVHPVHA GPIAPGQMRE PRGSDIAGTT 

       250        260        270        280        290        300 
STLQEQIGWM TNNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 

       310        320        330        340        350        360 
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC QGVGGPGHKA 

       370        380        390        400        410        420 
RVLAEAMSQV TNTATIMMQR GNFRNQRKMV KCFNCGKEGH TARNCRAPRK KGCWKCGKEG 

       430        440        450        460        470        480 
HQMKDCTERQ ANFLGKIWPS YKGRPGNFLQ SRPEPTAPPF LQSRPEPTAP PEESFRSGVE 

       490        500        510 
ATTPPQKQEP IDKELYPLTS LRSLFGNDPS SQ 

« Hide

References

[1]"Spectrum of biological properties of human immunodeficiency virus (HIV-1) isolates."
Cloyd M.W., Moore B.E.
Virology 174:103-116(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PM213 EMBL BAA12996.1.
[2]Iwatani Y.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PM213 EMBL BAA12996.1.
[3]"Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC)."
Morellet N., Demene H., Teilleux V., Huynh-Dinh T., de Rocquigny H., Fournie-Zaluski M.C., Roques B.P.
J. Mol. Biol. 283:419-434(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 390-430 IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86069 Genomic DNA. Translation: BAA12996.1.
PIRS49086.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ6NMR-A390-430[»]
ProteinModelPortalQ74084.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSPR00234. HIV1MATRIX.
SMARTSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ74084_9HIV1
AccessionPrimary (citable) accession number: Q74084
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)