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Q74084

- Q74084_9HIV1

UniProt

Q74084 - Q74084_9HIV1

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Protein
Submitted name: Gag
Gene
gag
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity.SAAS annotations
Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity.SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi392 – 3921Zinc 1Imported
Metal bindingi395 – 3951Zinc 1Imported
Metal bindingi400 – 4001Zinc 1; via tele nitrogenImported
Metal bindingi405 – 4051Zinc 1Imported
Metal bindingi413 – 4131Zinc 2Imported
Metal bindingi416 – 4161Zinc 2Imported
Metal bindingi421 – 4211Zinc 2; via tele nitrogenImported
Metal bindingi426 – 4261Zinc 2Imported

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. viral budding via host ESCRT complex Source: UniProtKB-KW
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotations, Virus exit from host cell

Keywords - Ligandi

Metal-binding, RNA-bindingSAAS annotations, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
GagImported
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion By similarity UniRule annotation. Virion By similarity SAAS annotations

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotations, Host cytoplasmUniRule annotationSAAS annotations, Host nucleusUniRule annotationSAAS annotations, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Post-translational modificationi

Specific enzymatic cleavages by the viral protease yield mature proteins By similarity.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BJ6NMR-A390-430[»]
ProteinModelPortaliQ74084.

Family & Domainsi

Sequence similaritiesi

Contains CCHC-type zinc fingers.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations, Zinc-fingerUniRule annotationSAAS annotations

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74084-1 [UniParc]FASTAAdd to Basket

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MGARASVLSG GKLDRWEKIR LRPGGKKKYK LKHIVWASRE LERFAVNPGL    50
LETSEGCRQI LGQLQPSLQT GSEERRSLYN TVATLYCVHQ RIEIKDTKEA 100
LDKIEEEQNK SKKKAQQAAA NTGHSSQVSQ NYPIVQNIQG QMVHQAISPR 150
TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM 200
LKETINEEAA EWDRVHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM 250
TNNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 300
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC 350
QGVGGPGHKA RVLAEAMSQV TNTATIMMQR GNFRNQRKMV KCFNCGKEGH 400
TARNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS YKGRPGNFLQ 450
SRPEPTAPPF LQSRPEPTAP PEESFRSGVE ATTPPQKQEP IDKELYPLTS 500
LRSLFGNDPS SQ 512
Length:512
Mass (Da):57,267
Last modified:November 1, 1996 - v1
Checksum:iAB5CC38B0414E085
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86069 Genomic DNA. Translation: BAA12996.1.
PIRiS49086.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotations

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86069 Genomic DNA. Translation: BAA12996.1 .
PIRi S49086.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BJ6 NMR - A 390-430 [» ]
ProteinModelPortali Q74084.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_N_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix_N.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view ]
PRINTSi PR00234. HIV1MATRIX.
SMARTi SM00343. ZnF_C2HC. 2 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEi PS50158. ZF_CCHC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spectrum of biological properties of human immunodeficiency virus (HIV-1) isolates."
    Cloyd M.W., Moore B.E.
    Virology 174:103-116(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PM213Imported.
  2. Iwatani Y.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PM213Imported.
  3. "Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC)."
    Morellet N., Demene H., Teilleux V., Huynh-Dinh T., de Rocquigny H., Fournie-Zaluski M.C., Roques B.P.
    J. Mol. Biol. 283:419-434(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 390-430 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ74084_9HIV1
AccessioniPrimary (citable) accession number: Q74084
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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