Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q74084

- Q74084_9HIV1

UniProt

Q74084 - Q74084_9HIV1

Protein
Submitted name:

Gag

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.SAAS annotation
    Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi392 – 3921Zinc 1Imported
    Metal bindingi395 – 3951Zinc 1Imported
    Metal bindingi400 – 4001Zinc 1; via tele nitrogenImported
    Metal bindingi405 – 4051Zinc 1Imported
    Metal bindingi413 – 4131Zinc 2Imported
    Metal bindingi416 – 4161Zinc 2Imported
    Metal bindingi421 – 4211Zinc 2; via tele nitrogenImported
    Metal bindingi426 – 4261Zinc 2Imported

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. viral budding via host ESCRT complex Source: UniProtKB-KW
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Virus exit from host cell

    Keywords - Ligandi

    Metal-binding, RNA-bindingSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GagImported
    Gene namesi
    Name:gagImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion UniRule annotation. Virion SAAS annotation

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-KW
    2. host cell nucleus Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Post-translational modificationi

    Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BJ6NMR-A390-430[»]
    ProteinModelPortaliQ74084.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains CCHC-type zinc fingers.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

    Family and domain databases

    Gene3Di1.10.1200.30. 1 hit.
    1.10.150.90. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProiIPR000721. Gag_p24.
    IPR014817. Gag_p6.
    IPR000071. Lentvrl_matrix_N.
    IPR012344. Matrix_N_HIV/RSV.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR010999. Retrovr_matrix_N.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00540. Gag_p17. 1 hit.
    PF00607. Gag_p24. 1 hit.
    PF08705. Gag_p6. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view]
    PRINTSiPR00234. HIV1MATRIX.
    SMARTiSM00343. ZnF_C2HC. 2 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    SSF47836. SSF47836. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEiPS50158. ZF_CCHC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q74084-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGARASVLSG GKLDRWEKIR LRPGGKKKYK LKHIVWASRE LERFAVNPGL    50
    LETSEGCRQI LGQLQPSLQT GSEERRSLYN TVATLYCVHQ RIEIKDTKEA 100
    LDKIEEEQNK SKKKAQQAAA NTGHSSQVSQ NYPIVQNIQG QMVHQAISPR 150
    TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM 200
    LKETINEEAA EWDRVHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM 250
    TNNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 300
    YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC 350
    QGVGGPGHKA RVLAEAMSQV TNTATIMMQR GNFRNQRKMV KCFNCGKEGH 400
    TARNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS YKGRPGNFLQ 450
    SRPEPTAPPF LQSRPEPTAP PEESFRSGVE ATTPPQKQEP IDKELYPLTS 500
    LRSLFGNDPS SQ 512
    Length:512
    Mass (Da):57,267
    Last modified:November 1, 1996 - v1
    Checksum:iAB5CC38B0414E085
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86069 Genomic DNA. Translation: BAA12996.1.
    PIRiS49086.

    Keywords - Coding sequence diversityi

    Ribosomal frameshiftingSAAS annotation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86069 Genomic DNA. Translation: BAA12996.1 .
    PIRi S49086.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BJ6 NMR - A 390-430 [» ]
    ProteinModelPortali Q74084.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1200.30. 1 hit.
    1.10.150.90. 1 hit.
    1.10.375.10. 1 hit.
    4.10.60.10. 1 hit.
    InterProi IPR000721. Gag_p24.
    IPR014817. Gag_p6.
    IPR000071. Lentvrl_matrix_N.
    IPR012344. Matrix_N_HIV/RSV.
    IPR008916. Retrov_capsid_C.
    IPR008919. Retrov_capsid_N.
    IPR010999. Retrovr_matrix_N.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00540. Gag_p17. 1 hit.
    PF00607. Gag_p24. 1 hit.
    PF08705. Gag_p6. 1 hit.
    PF00098. zf-CCHC. 2 hits.
    [Graphical view ]
    PRINTSi PR00234. HIV1MATRIX.
    SMARTi SM00343. ZnF_C2HC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    SSF47836. SSF47836. 1 hit.
    SSF47943. SSF47943. 1 hit.
    SSF57756. SSF57756. 1 hit.
    PROSITEi PS50158. ZF_CCHC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spectrum of biological properties of human immunodeficiency virus (HIV-1) isolates."
      Cloyd M.W., Moore B.E.
      Virology 174:103-116(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PM213Imported.
    2. Iwatani Y.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PM213Imported.
    3. "Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC)."
      Morellet N., Demene H., Teilleux V., Huynh-Dinh T., de Rocquigny H., Fournie-Zaluski M.C., Roques B.P.
      J. Mol. Biol. 283:419-434(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 390-430 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiQ74084_9HIV1
    AccessioniPrimary (citable) accession number: Q74084
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3