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Q73ZQ6

- GCSP_MYCPA

UniProt

Q73ZQ6 - GCSP_MYCPA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-1567-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:MAP_1545
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 941941Glycine dehydrogenase (decarboxylating)PRO_0000227107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei692 – 6921N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi262316.MAP1545.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73ZQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiFHQYRSE.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q73ZQ6-1 [UniParc]FASTAAdd to Basket

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    MPDHTTFAAR HIGPDPQAVA AMLDVIGVGS LDELAAKAVP AGIRDRLSAD    50
    GIAPGLDRLP PPASETEALA ELRGLAEANT VAVSMIGQGY YDTLTPPVLL 100
    RNILENPAWY TAYTPYQPEI SQGRLEALLN FQTMVADLTG LEIANASMLD 150
    EGTAAAEAMT LMRRASRGKS NRLAVDADVF AQTAAIVATR ARPLGIEIVT 200
    ADLRDGLPDG DFFGVIAQLP GASGAITDWA ALVAQAHERG ALVALGADLL 250
    ALTLITPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH ANHARQLPGR 300
    LVGVSLDADG SPAYRLALQT REQHIRRDKA TSNICTAQVL LAVMAAMYAS 350
    YHGAEGLTAI ARRVHGHAEA IAAALGTAVV HDRYFDTVLA RVPGRADEVI 400
    AAAKARGINL WRVDDDHVSV ACDEATTDEH VAAVLEAFGV APAEPVASEI 450
    ATRTAEFLTH PAFTQYRTET AMMRYLRTLA DKDIALDRSM IPLGSCTMKL 500
    NAAAEMEPIT WPEFARQHPF APASDTPGLR RLIGDLENWL VAITGYDAVS 550
    LQPNAGSQGE YAGLLAIHDY HASRGEPHRD ICLIPSSAHG TNAASAALAG 600
    MRVVVVGCHD NGDVDLDDLR AKVTEHRDRL STLMITYPST HGVYEHDIAE 650
    ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG 700
    GGPGVGPVAV RSHLAPFLPG HPHAPELPQG HPVSSAPYGS ASILPISWAY 750
    IRMMGADGLR AASLTAITSA NYIARRLDEY FPVLYTGENG MVAHECILDL 800
    RPITKATGVT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESETLTEVD 850
    AFCDAMIAIR GEIDRVGAGE WPVEDNPLRG APHTAECLVT TDWDHPYSRE 900
    QAAYPLGKDF RPKVWPPVRR IDGAYGDRNL VCSCPPVEAF A 941
    Length:941
    Mass (Da):99,928
    Last modified:July 5, 2004 - v1
    Checksum:i70BFCDC8948B1BF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03862.1.
    RefSeqiNP_960479.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS03862; AAS03862; MAP_1545.
    GeneIDi2717795.
    KEGGimpa:MAP1545.
    PATRICi17995616. VBIMycAvi108102_1636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03862.1 .
    RefSeqi NP_960479.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q73ZQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP1545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS03862 ; AAS03862 ; MAP_1545 .
    GeneIDi 2717795.
    KEGGi mpa:MAP1545.
    PATRICi 17995616. VBIMycAvi108102_1636.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi FHQYRSE.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci MAVI262316:GCQR-1567-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiGCSP_MYCPA
    AccessioniPrimary (citable) accession number: Q73ZQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3