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Q73ZQ6

- GCSP_MYCPA

UniProt

Q73ZQ6 - GCSP_MYCPA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1567-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:MAP_1545
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Glycine dehydrogenase (decarboxylating)PRO_0000227107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei692 – 6921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi262316.MAP1545.

Structurei

3D structure databases

ProteinModelPortaliQ73ZQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFHQYRSE.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73ZQ6-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPDHTTFAAR HIGPDPQAVA AMLDVIGVGS LDELAAKAVP AGIRDRLSAD
60 70 80 90 100
GIAPGLDRLP PPASETEALA ELRGLAEANT VAVSMIGQGY YDTLTPPVLL
110 120 130 140 150
RNILENPAWY TAYTPYQPEI SQGRLEALLN FQTMVADLTG LEIANASMLD
160 170 180 190 200
EGTAAAEAMT LMRRASRGKS NRLAVDADVF AQTAAIVATR ARPLGIEIVT
210 220 230 240 250
ADLRDGLPDG DFFGVIAQLP GASGAITDWA ALVAQAHERG ALVALGADLL
260 270 280 290 300
ALTLITPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH ANHARQLPGR
310 320 330 340 350
LVGVSLDADG SPAYRLALQT REQHIRRDKA TSNICTAQVL LAVMAAMYAS
360 370 380 390 400
YHGAEGLTAI ARRVHGHAEA IAAALGTAVV HDRYFDTVLA RVPGRADEVI
410 420 430 440 450
AAAKARGINL WRVDDDHVSV ACDEATTDEH VAAVLEAFGV APAEPVASEI
460 470 480 490 500
ATRTAEFLTH PAFTQYRTET AMMRYLRTLA DKDIALDRSM IPLGSCTMKL
510 520 530 540 550
NAAAEMEPIT WPEFARQHPF APASDTPGLR RLIGDLENWL VAITGYDAVS
560 570 580 590 600
LQPNAGSQGE YAGLLAIHDY HASRGEPHRD ICLIPSSAHG TNAASAALAG
610 620 630 640 650
MRVVVVGCHD NGDVDLDDLR AKVTEHRDRL STLMITYPST HGVYEHDIAE
660 670 680 690 700
ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG
710 720 730 740 750
GGPGVGPVAV RSHLAPFLPG HPHAPELPQG HPVSSAPYGS ASILPISWAY
760 770 780 790 800
IRMMGADGLR AASLTAITSA NYIARRLDEY FPVLYTGENG MVAHECILDL
810 820 830 840 850
RPITKATGVT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESETLTEVD
860 870 880 890 900
AFCDAMIAIR GEIDRVGAGE WPVEDNPLRG APHTAECLVT TDWDHPYSRE
910 920 930 940
QAAYPLGKDF RPKVWPPVRR IDGAYGDRNL VCSCPPVEAF A
Length:941
Mass (Da):99,928
Last modified:July 5, 2004 - v1
Checksum:i70BFCDC8948B1BF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03862.1.
RefSeqiNP_960479.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS03862; AAS03862; MAP_1545.
GeneIDi2717795.
KEGGimpa:MAP1545.
PATRICi17995616. VBIMycAvi108102_1636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS03862.1 .
RefSeqi NP_960479.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73ZQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP1545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS03862 ; AAS03862 ; MAP_1545 .
GeneIDi 2717795.
KEGGi mpa:MAP1545.
PATRICi 17995616. VBIMycAvi108102_1636.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FHQYRSE.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci MAVI262316:GCQR-1567-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiGCSP_MYCPA
AccessioniPrimary (citable) accession number: Q73ZQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3