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Q73ZQ6 (GCSP_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:MAP_1545
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length941 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 941941Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227107

Amino acid modifications

Modified residue6921N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73ZQ6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 70BFCDC8948B1BF3

FASTA94199,928
        10         20         30         40         50         60 
MPDHTTFAAR HIGPDPQAVA AMLDVIGVGS LDELAAKAVP AGIRDRLSAD GIAPGLDRLP 

        70         80         90        100        110        120 
PPASETEALA ELRGLAEANT VAVSMIGQGY YDTLTPPVLL RNILENPAWY TAYTPYQPEI 

       130        140        150        160        170        180 
SQGRLEALLN FQTMVADLTG LEIANASMLD EGTAAAEAMT LMRRASRGKS NRLAVDADVF 

       190        200        210        220        230        240 
AQTAAIVATR ARPLGIEIVT ADLRDGLPDG DFFGVIAQLP GASGAITDWA ALVAQAHERG 

       250        260        270        280        290        300 
ALVALGADLL ALTLITPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH ANHARQLPGR 

       310        320        330        340        350        360 
LVGVSLDADG SPAYRLALQT REQHIRRDKA TSNICTAQVL LAVMAAMYAS YHGAEGLTAI 

       370        380        390        400        410        420 
ARRVHGHAEA IAAALGTAVV HDRYFDTVLA RVPGRADEVI AAAKARGINL WRVDDDHVSV 

       430        440        450        460        470        480 
ACDEATTDEH VAAVLEAFGV APAEPVASEI ATRTAEFLTH PAFTQYRTET AMMRYLRTLA 

       490        500        510        520        530        540 
DKDIALDRSM IPLGSCTMKL NAAAEMEPIT WPEFARQHPF APASDTPGLR RLIGDLENWL 

       550        560        570        580        590        600 
VAITGYDAVS LQPNAGSQGE YAGLLAIHDY HASRGEPHRD ICLIPSSAHG TNAASAALAG 

       610        620        630        640        650        660 
MRVVVVGCHD NGDVDLDDLR AKVTEHRDRL STLMITYPST HGVYEHDIAE ICAAVHDAGG 

       670        680        690        700        710        720 
QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG GGPGVGPVAV RSHLAPFLPG 

       730        740        750        760        770        780 
HPHAPELPQG HPVSSAPYGS ASILPISWAY IRMMGADGLR AASLTAITSA NYIARRLDEY 

       790        800        810        820        830        840 
FPVLYTGENG MVAHECILDL RPITKATGVT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP 

       850        860        870        880        890        900 
TESETLTEVD AFCDAMIAIR GEIDRVGAGE WPVEDNPLRG APHTAECLVT TDWDHPYSRE 

       910        920        930        940 
QAAYPLGKDF RPKVWPPVRR IDGAYGDRNL VCSCPPVEAF A 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS03862.1.
RefSeqNP_960479.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73ZQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP1545.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS03862; AAS03862; MAP_1545.
GeneID2717795.
KEGGmpa:MAP1545.
PATRIC17995616. VBIMycAvi108102_1636.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-1567-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_MYCPA
AccessionPrimary (citable) accession number: Q73ZQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families