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Q73ZP4 (Q73ZP4_MYCPA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL AAS03874.1
Ordered Locus Names:MAP_1557c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding21 – 266NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding44 – 463NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding86 – 883NADP By similarity PIRSR PIRSR000109-3
Region140 – 1423Substrate binding By similarity PIRSR PIRSR000109-2
Region197 – 1982Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1941Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2011Proton donor By similarity PIRSR PIRSR000109-1
Binding site1141NADP By similarity PIRSR PIRSR000109-3
Binding site1141Substrate By similarity PIRSR PIRSR000109-2
Binding site2021Substrate By similarity PIRSR PIRSR000109-2
Binding site2721Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2991Substrate By similarity PIRSR PIRSR000109-2
Binding site4571Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4631Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q73ZP4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FB87E70E70B5EEC0

FASTA48952,787
        10         20         30         40         50         60 
MSSSVTPSRP TTGTAQIGVT GLAVMGSNIA RNFARHGYTV ALHNRSIAKT DALLKEHGDE 

        70         80         90        100        110        120 
GKFVRCETIA EFLDALEKPR RVLIMVKAGD PTDAVINELA DAMEPGDIII DGGNALYTDT 

       130        140        150        160        170        180 
IRREQAMRER GLHFVGAGIS GGEEGALNGP SIMPGGPAES YRSLGPLLEE ISAHVDGVPC 

       190        200        210        220        230        240 
CTHIGPDGAG HFVKMVHNGI EYSDMQLIGE AYQLLRDALG KTAEQIADVF DEWNSGDLDS 

       250        260        270        280        290        300 
FLVEITAQVL RQTDAKTGKP LVDLILDEAE QKGTGRWTVK SALDLGVPVT GIAEAVFARA 

       310        320        330        340        350        360 
LSGSVAQRRA TTGLASGRFG EKPSDAAQFT EDIRQALYAS KIIAYAQGFN QIQAGSAEYG 

       370        380        390        400        410        420 
WDITPGDLAT IWRGGCIIRA KFLNRIKDAF DENPDLPTLI VAPYFRSAIE AAIDGWRRVV 

       430        440        450        460        470        480 
VTATRLGIPI PGFSSALSYY DALRTERLPA ALTQGLRDFF GAHTYGRIDE DPDKRFHTLW 


SADRREVPA

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References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS03874.1.
RefSeqNP_960491.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73ZP4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000038531; EBMYCP00000036920; EBMYCG00000038526.
GeneID2719540.
GenomeReviewsGene locus MAP_1557c in contig AE016958_GR.
KEGGmpa:MAP1557c.
NMPDRfig|262316.1.peg.1557.
PATRIC17995642. VBIMycAvi108102_1649.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ73ZP4_MYCPA
AccessionPrimary (citable) accession number: Q73ZP4
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info