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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1920-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:MAP_1897c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000225068Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1897c.

Structurei

3D structure databases

ProteinModelPortaliQ73YQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
KOiK02563.
OMAiHQTKNAM.
OrthoDBiPOG091H02FX.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73YQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTVKKPTG GRGDDPLPAG AALSAVAPHE PVSVVLAGGG TAGHVEPAMA
60 70 80 90 100
VADALKALDP HVRITALGTA RGLETRLVPE RGYDLELITP VPLPRKPTGD
110 120 130 140 150
LARLPSRVWR AVRETRAVLH AVDADVVIGF GGYVALPAYL AARGVSPRKP
160 170 180 190 200
RVPVVIHEAN ASAGLANRVG ARTAQRVLSA VPDCGLPGAE VVGVPVREAI
210 220 230 240 250
TSLDRAALRA EARRHFGFAD DARVLLVFGG SQGAASLNRA VSGAAAQLAA
260 270 280 290 300
AGVSVLHAHG PKNTLDLREP QPGDPPYVAV PYLDRMDLAY AAADLVICRS
310 320 330 340 350
GAMTVAEVSA VGLPAIYVPL PIGNGEQRLN ALPVVDAGGG MVVADADLTP
360 370 380 390 400
ELVAREVAGL VGDPPRLAAM TTAAARVGHP DAARRVAQAA LDIGRTARLA

RGATGGRP
Length:408
Mass (Da):41,699
Last modified:July 5, 2004 - v1
Checksum:i1F5A2B379BC16A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS04214.1.
RefSeqiWP_003878116.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS04214; AAS04214; MAP_1897c.
GeneIDi2719384.
KEGGimpa:MAP_1897c.
PATRICi17996368. VBIMycAvi108102_2011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS04214.1.
RefSeqiWP_003878116.1. NC_002944.2.

3D structure databases

ProteinModelPortaliQ73YQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP1897c.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS04214; AAS04214; MAP_1897c.
GeneIDi2719384.
KEGGimpa:MAP_1897c.
PATRICi17996368. VBIMycAvi108102_2011.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
KOiK02563.
OMAiHQTKNAM.
OrthoDBiPOG091H02FX.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMAVI262316:GCQR-1920-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURG_MYCPA
AccessioniPrimary (citable) accession number: Q73YQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.