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Q73YL5 (COX2_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Ordered Locus Names:MAP_1940c
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Chain40 – 360321Probable cytochrome c oxidase subunit 2
PRO_0000006057

Regions

Transmembrane70 – 9021Helical; Potential
Transmembrane117 – 13721Helical; Potential

Sites

Metal binding2531Copper A Potential
Metal binding2941Copper A Potential
Metal binding2981Copper A Potential
Metal binding3021Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q73YL5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AF033EDF7A79D1FC

FASTA36039,922
        10         20         30         40         50         60 
MTPREQDRSQ PLSQGRFPGR VGRRVLRPLA LAVTLGVLAI VLSGCSSWAD ALALGWPKGI 

        70         80         90        100        110        120 
TPQAHLNREL WIGAVIASLV VGAIVYGLIF WASAFHRKKA TDTELPRQFG YNMPLELVLT 

       130        140        150        160        170        180 
VTPFLIISVL FYFTVVVQEK MLHIAKDPEV VVDVTAFQWN WKFGYQKVNF KDGTLTYDGA 

       190        200        210        220        230        240 
DPERKKAMVS KPEGKDAHGE ERVGAVRGLN TSDRTYLNFD KVETLGSSDE IPVLVLPTGK 

       250        260        270        280        290        300 
RIEFDLASAD VVHTFWVPEF LFKRDVIPNA EANNSIHVFQ VEEINSPGAF VGHCAEFCGT 

       310        320        330        340        350        360 
YHSMMNFEVR VVSPNDFKAY LQQRMDGKSN AEALQAIGQS PVAVTTHPFD SKRGQLAGSQ 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS04257.1.
RefSeqNP_960874.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73YL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP1940c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS04257; AAS04257; MAP_1940c.
GeneID2720228.
KEGGmpa:MAP1940c.
PATRIC17996460. VBIMycAvi108102_2057.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
KOK02275.
OMAMRELWTW.
OrthoDBEOG68SVXT.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-1963-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MYCPA
AccessionPrimary (citable) accession number: Q73YL5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families