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Q73YL5

- COX2_MYCPA

UniProt

Q73YL5 - COX2_MYCPA

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Protein
Probable cytochrome c oxidase subunit 2
Gene
ctaC, MAP_1940c
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A By similarity.
Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi253 – 2531Copper A Reviewed prediction
Metal bindingi294 – 2941Copper A Reviewed prediction
Metal bindingi298 – 2981Copper A Reviewed prediction
Metal bindingi302 – 3021Copper A Reviewed prediction

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:MAP_1940c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 Reviewed prediction
Add
BLAST
Chaini40 – 360321Probable cytochrome c oxidase subunit 2
PRO_0000006057Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1940c.

Structurei

3D structure databases

ProteinModelPortaliQ73YL5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
KOiK02275.
OMAiMRELWTW.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73YL5-1 [UniParc]FASTAAdd to Basket

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MTPREQDRSQ PLSQGRFPGR VGRRVLRPLA LAVTLGVLAI VLSGCSSWAD    50
ALALGWPKGI TPQAHLNREL WIGAVIASLV VGAIVYGLIF WASAFHRKKA 100
TDTELPRQFG YNMPLELVLT VTPFLIISVL FYFTVVVQEK MLHIAKDPEV 150
VVDVTAFQWN WKFGYQKVNF KDGTLTYDGA DPERKKAMVS KPEGKDAHGE 200
ERVGAVRGLN TSDRTYLNFD KVETLGSSDE IPVLVLPTGK RIEFDLASAD 250
VVHTFWVPEF LFKRDVIPNA EANNSIHVFQ VEEINSPGAF VGHCAEFCGT 300
YHSMMNFEVR VVSPNDFKAY LQQRMDGKSN AEALQAIGQS PVAVTTHPFD 350
SKRGQLAGSQ 360
Length:360
Mass (Da):39,922
Last modified:July 5, 2004 - v1
Checksum:iAF033EDF7A79D1FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS04257.1.
RefSeqiNP_960874.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS04257; AAS04257; MAP_1940c.
GeneIDi2720228.
KEGGimpa:MAP1940c.
PATRICi17996460. VBIMycAvi108102_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS04257.1 .
RefSeqi NP_960874.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73YL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP1940c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS04257 ; AAS04257 ; MAP_1940c .
GeneIDi 2720228.
KEGGi mpa:MAP1940c.
PATRICi 17996460. VBIMycAvi108102_2057.

Phylogenomic databases

eggNOGi COG1622.
KOi K02275.
OMAi MRELWTW.
OrthoDBi EOG68SVXT.

Enzyme and pathway databases

BioCyci MAVI262316:GCQR-1963-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiCOX2_MYCPA
AccessioniPrimary (citable) accession number: Q73YL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi