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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi253 – 2531Copper ASequence Analysis
Metal bindingi294 – 2941Copper ASequence Analysis
Metal bindingi298 – 2981Copper ASequence Analysis
Metal bindingi302 – 3021Copper ASequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1963-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:MAP_1940c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 360321Probable cytochrome c oxidase subunit 2PRO_0000006057Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1940c.

Structurei

3D structure databases

ProteinModelPortaliQ73YL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
KOiK02275.
OMAiVLRFGWP.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73YL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPREQDRSQ PLSQGRFPGR VGRRVLRPLA LAVTLGVLAI VLSGCSSWAD
60 70 80 90 100
ALALGWPKGI TPQAHLNREL WIGAVIASLV VGAIVYGLIF WASAFHRKKA
110 120 130 140 150
TDTELPRQFG YNMPLELVLT VTPFLIISVL FYFTVVVQEK MLHIAKDPEV
160 170 180 190 200
VVDVTAFQWN WKFGYQKVNF KDGTLTYDGA DPERKKAMVS KPEGKDAHGE
210 220 230 240 250
ERVGAVRGLN TSDRTYLNFD KVETLGSSDE IPVLVLPTGK RIEFDLASAD
260 270 280 290 300
VVHTFWVPEF LFKRDVIPNA EANNSIHVFQ VEEINSPGAF VGHCAEFCGT
310 320 330 340 350
YHSMMNFEVR VVSPNDFKAY LQQRMDGKSN AEALQAIGQS PVAVTTHPFD
360
SKRGQLAGSQ
Length:360
Mass (Da):39,922
Last modified:July 5, 2004 - v1
Checksum:iAF033EDF7A79D1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS04257.1.
RefSeqiNP_960874.1. NC_002944.2.
WP_003872270.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS04257; AAS04257; MAP_1940c.
GeneIDi2720228.
KEGGimpa:MAP1940c.
PATRICi17996460. VBIMycAvi108102_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS04257.1.
RefSeqiNP_960874.1. NC_002944.2.
WP_003872270.1. NC_002944.2.

3D structure databases

ProteinModelPortaliQ73YL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP1940c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS04257; AAS04257; MAP_1940c.
GeneIDi2720228.
KEGGimpa:MAP1940c.
PATRICi17996460. VBIMycAvi108102_2057.

Phylogenomic databases

eggNOGiCOG1622.
KOiK02275.
OMAiVLRFGWP.
OrthoDBiEOG68SVXT.

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1963-MONOMER.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiCOX2_MYCPA
AccessioniPrimary (citable) accession number: Q73YL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.