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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi253Copper ASequence analysis1
Metal bindingi294Copper ASequence analysis1
Metal bindingi298Copper ASequence analysis1
Metal bindingi302Copper ASequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:MAP_1940c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000000605740 – 360Probable cytochrome c oxidase subunit 2Add BLAST321

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1940c

Structurei

3D structure databases

ProteinModelPortaliQ73YL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
KOiK02275
OMAiHAFMPIA
OrthoDBiPOG091H05L4

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 2 hits
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73YL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPREQDRSQ PLSQGRFPGR VGRRVLRPLA LAVTLGVLAI VLSGCSSWAD
60 70 80 90 100
ALALGWPKGI TPQAHLNREL WIGAVIASLV VGAIVYGLIF WASAFHRKKA
110 120 130 140 150
TDTELPRQFG YNMPLELVLT VTPFLIISVL FYFTVVVQEK MLHIAKDPEV
160 170 180 190 200
VVDVTAFQWN WKFGYQKVNF KDGTLTYDGA DPERKKAMVS KPEGKDAHGE
210 220 230 240 250
ERVGAVRGLN TSDRTYLNFD KVETLGSSDE IPVLVLPTGK RIEFDLASAD
260 270 280 290 300
VVHTFWVPEF LFKRDVIPNA EANNSIHVFQ VEEINSPGAF VGHCAEFCGT
310 320 330 340 350
YHSMMNFEVR VVSPNDFKAY LQQRMDGKSN AEALQAIGQS PVAVTTHPFD
360
SKRGQLAGSQ
Length:360
Mass (Da):39,922
Last modified:July 5, 2004 - v1
Checksum:iAF033EDF7A79D1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS04257.1
RefSeqiWP_003872270.1, NC_002944.2

Genome annotation databases

EnsemblBacteriaiAAS04257; AAS04257; MAP_1940c
GeneIDi2720228
KEGGimpa:MAP_1940c

Similar proteinsi

Entry informationi

Entry nameiCOX2_MYCPA
AccessioniPrimary (citable) accession number: Q73YL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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