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Q73YL5

- COX2_MYCPA

UniProt

Q73YL5 - COX2_MYCPA

Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi253 – 2531Copper ASequence Analysis
    Metal bindingi294 – 2941Copper ASequence Analysis
    Metal bindingi298 – 2981Copper ASequence Analysis
    Metal bindingi302 – 3021Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-1963-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:ctaC
    Ordered Locus Names:MAP_1940c
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 360321Probable cytochrome c oxidase subunit 2PRO_0000006057Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262316.MAP1940c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73YL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q73YL5-1 [UniParc]FASTAAdd to Basket

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    MTPREQDRSQ PLSQGRFPGR VGRRVLRPLA LAVTLGVLAI VLSGCSSWAD    50
    ALALGWPKGI TPQAHLNREL WIGAVIASLV VGAIVYGLIF WASAFHRKKA 100
    TDTELPRQFG YNMPLELVLT VTPFLIISVL FYFTVVVQEK MLHIAKDPEV 150
    VVDVTAFQWN WKFGYQKVNF KDGTLTYDGA DPERKKAMVS KPEGKDAHGE 200
    ERVGAVRGLN TSDRTYLNFD KVETLGSSDE IPVLVLPTGK RIEFDLASAD 250
    VVHTFWVPEF LFKRDVIPNA EANNSIHVFQ VEEINSPGAF VGHCAEFCGT 300
    YHSMMNFEVR VVSPNDFKAY LQQRMDGKSN AEALQAIGQS PVAVTTHPFD 350
    SKRGQLAGSQ 360
    Length:360
    Mass (Da):39,922
    Last modified:July 5, 2004 - v1
    Checksum:iAF033EDF7A79D1FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS04257.1.
    RefSeqiNP_960874.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS04257; AAS04257; MAP_1940c.
    GeneIDi2720228.
    KEGGimpa:MAP1940c.
    PATRICi17996460. VBIMycAvi108102_2057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS04257.1 .
    RefSeqi NP_960874.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q73YL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP1940c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS04257 ; AAS04257 ; MAP_1940c .
    GeneIDi 2720228.
    KEGGi mpa:MAP1940c.
    PATRICi 17996460. VBIMycAvi108102_2057.

    Phylogenomic databases

    eggNOGi COG1622.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.

    Enzyme and pathway databases

    BioCyci MAVI262316:GCQR-1963-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiCOX2_MYCPA
    AccessioniPrimary (citable) accession number: Q73YL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3