Q73XV0 (SIR2_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfite reductase [ferredoxin] 2
EC=1.8.7.1

Gene names

Name:	sir2
Synonyms:	nirA2
Ordered Locus Names:	MAP_2208

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+.
Cofactor	Binds 1 siroheme per subunit By similarity. Binds 1 4Fe-4S cluster per subunit By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Ontologies

Keywords
Ligand	4Fe-4S Heme Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW heme binding Inferred from electronic annotation. Source: InterPro sulfite reductase (ferredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Sulfite reductase [ferredoxin] 2		PRO_0000199951
Sites
	Metal binding	417	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	423	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	463	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	467	1	Iron (siroheme axial ligand) By similarity
	Metal binding	467	1	Iron-sulfur (4Fe-4S) By similarity
Amino acid modifications
	Cross-link	69 ↔ 161		3'-(S-cysteinyl)-tyrosine (Tyr-Cys) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73XV0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 05317F4EEE477BF6	FASTA	555	61,868
	10 20 30 40 50 60 MTTARPAKAR NEGQWALGNR EPLNPNEEMK QAGAPLAVRE RIETIYAKNG FDSIDKSDLR 70 80 90 100 110 120 GRFRWWGLYT QREQGYDGSW TGDENIEKLE ARYFMMRVRC DGGAISAAAL RTLGQISVDF 130 140 150 160 170 180 ARDTADITDR ENIQYHWIEV ENVPEIWRRL DAVGLRTTEA CGDCPRVILG SPLAGESLEE 190 200 210 220 230 240 VIDPSWAIAE IARRYIGQPD FADLPRKYKT AISGLQDVAH EVNDVAFIGV NHPEHGPGLD 250 260 270 280 290 300 LWVGGGLSTN PMLAQRVGAW VPLHEVPEVW AAVTSVFRDY GYRRLRSKAR LKFLVKDWGI 310 320 330 340 350 360 EKFREVLETE YLKRPLIDGP APEPVAHPID HVGVQRLKNG LNAVGVAPIA GRVSGTILLA 370 380 390 400 410 420 VADLAQQAGC DRIRFTPYQK LVLLDIPDDK LDEVVAGLEA LGLQSQPSHW RRNLMACSGI 430 440 450 460 470 480 EFCKLSFAET RVRAQGLVPE LERRLADVNR QLDVPITINL NGCPNSCARI QVADIGLKGQ 490 500 510 520 530 540 MVDDGEGGSV EGFQVHLGGS LGQDSGFGRK LRQHKVTSDE LGDYIERVAR NFVKYRGEGE 550 RFAQWAMRAD EDDLR

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS04525.1.
RefSeq	NP_961142.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73XV0.
SMR	Q73XV0. Positions 10-555.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000037265; EBMYCP00000035654; EBMYCG00000037260.
GeneID	2718803.
GenomeReviews	Gene locus MAP_2208 in contig AE016958_GR.
KEGG	mpa:MAP2208.
NMPDR	fig|262316.1.peg.2208.
PATRIC	17997048. VBIMycAvi108102_2348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015728.
HOGENOM	HBG578916.
OMA	DQLERWQ.
ProtClustDB	CLSK872057.
Family and domain databases
InterPro	IPR005117. NiRdtase/SiRdtase_haem-b_fer. IPR006067. NO2/SO3_Rdtase_4Fe4S_dom. IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS. [Graphical view]
Gene3D	G3DSA:3.90.480.10. G3DSA:3.90.480.10. 2 hits.
KO	K00366.
Pfam	PF01077. NIR_SIR. 2 hits. PF03460. NIR_SIR_ferr. 2 hits. [Graphical view]
PRINTS	PR00397. SIROHAEM.
SUPFAM	SSF55124. NiR_SiRalpha_1/3. 2 hits.
PROSITE	PS00365. NIR_SIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIR2_MYCPA

Accession

Primary (citable) accession number: Q73XV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program