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Reviewed, UniProtKB/Swiss-Prot Q73XV0 (SIR2_MYCPA)

Last modified November 25, 2008. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sulfite reductase [ferredoxin] 2
    EC=1.8.7.1
Gene names
Name: sir2
Synonyms: nirA2
Ordered Locus Names: MAP_2208
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Hydrogen sulfide + 6 oxidized ferredoxin + 3 H(2)O = sulfite + 6 reduced ferredoxin + 6 H(+).

Cofactor

Binds 1 siroheme per subunit By similarity.

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Sulfite reductase [ferredoxin] 2
PRO_0000199951

Sites

Metal binding4171Iron-sulfur (4Fe-4S) By similarity
Metal binding4231Iron-sulfur (4Fe-4S) By similarity
Metal binding4631Iron-sulfur (4Fe-4S) By similarity
Metal binding4671Iron (siroheme axial ligand) By similarity
Metal binding4671Iron-sulfur (4Fe-4S) By similarity

Amino acid modifications

Cross-link69 ↔ 1613'-(S-cysteinyl)-tyrosine (Tyr-Cys) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73XV0-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 05317F4EEE477BF6

FASTA55561,868
        10         20         30         40         50         60 
MTTARPAKAR NEGQWALGNR EPLNPNEEMK QAGAPLAVRE RIETIYAKNG FDSIDKSDLR 

        70         80         90        100        110        120 
GRFRWWGLYT QREQGYDGSW TGDENIEKLE ARYFMMRVRC DGGAISAAAL RTLGQISVDF 

       130        140        150        160        170        180 
ARDTADITDR ENIQYHWIEV ENVPEIWRRL DAVGLRTTEA CGDCPRVILG SPLAGESLEE 

       190        200        210        220        230        240 
VIDPSWAIAE IARRYIGQPD FADLPRKYKT AISGLQDVAH EVNDVAFIGV NHPEHGPGLD 

       250        260        270        280        290        300 
LWVGGGLSTN PMLAQRVGAW VPLHEVPEVW AAVTSVFRDY GYRRLRSKAR LKFLVKDWGI 

       310        320        330        340        350        360 
EKFREVLETE YLKRPLIDGP APEPVAHPID HVGVQRLKNG LNAVGVAPIA GRVSGTILLA 

       370        380        390        400        410        420 
VADLAQQAGC DRIRFTPYQK LVLLDIPDDK LDEVVAGLEA LGLQSQPSHW RRNLMACSGI 

       430        440        450        460        470        480 
EFCKLSFAET RVRAQGLVPE LERRLADVNR QLDVPITINL NGCPNSCARI QVADIGLKGQ 

       490        500        510        520        530        540 
MVDDGEGGSV EGFQVHLGGS LGQDSGFGRK LRQHKVTSDE LGDYIERVAR NFVKYRGEGE 

       550 
RFAQWAMRAD EDDLR 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

AE016958 Genomic DNA. Translation: AAS04525.1.
RefSeqNP_961142.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2718803.
GenomeReviewsGene locus MAP_2208 in contig AE016958_GR.
KEGGmpa:MAP2208.
NMPDRfig|262316.1.peg.2208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ73XV0.

Family and domain databases

InterProIPR006066. Nir_Si_BS.
IPR006067. Nir_Sir_4Fe4S.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
[Graphical view]
PfamPF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIR2_MYCPA
AccessionPrimary (citable) accession number: Q73XV0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents