Q73XV0 (SIR2_MYCPA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Sulfite reductase [ferredoxin] 2 EC=1.8.7.1 | ||||||
| Gene names |
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| Organism | Mycobacterium paratuberculosis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1770 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) |
Protein attributes
| Sequence length | 555 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+. |
| Cofactor | Binds 1 siroheme per subunit By similarity. Binds 1 4Fe-4S cluster per subunit By similarity. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | 4Fe-4S Heme Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Thioether bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW heme bindingInferred from electronic annotation. Source: InterPro sulfite reductase (ferredoxin) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 555 | 555 | Sulfite reductase [ferredoxin] 2 | PRO_0000199951 | |||||||
Sites | |||||||||||
| Metal binding | 417 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||||
| Metal binding | 423 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||||
| Metal binding | 463 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||||
| Metal binding | 467 | 1 | Iron (siroheme axial ligand) By similarity | ||||||||
| Metal binding | 467 | 1 | Iron-sulfur (4Fe-4S) By similarity | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 69 ↔ 161 | 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) By similarity | |||||||||
Sequences
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References
| [1] | "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016958 Genomic DNA. Translation: AAS04525.1. |
| RefSeq | NP_961142.1. NC_002944.2. |
3D structure databases | |
| ProteinModelPortal | Q73XV0. |
| SMR | Q73XV0. Positions 10-555. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000037265; EBMYCP00000035654; EBMYCG00000037260. |
| GeneID | 2718803. |
| GenomeReviews | Gene locus MAP_2208 in contig AE016958_GR. |
| KEGG | mpa:MAP2208. |
| NMPDR | fig|262316.1.peg.2208. |
| PATRIC | 17997048. VBIMycAvi108102_2348. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000015728. |
| HOGENOM | HBG578916. |
| OMA | DQLERWQ. |
| ProtClustDB | CLSK872057. |
Family and domain databases | |
| InterPro | IPR005117. NiRdtase/SiRdtase_haem-b_fer. IPR006067. NO2/SO3_Rdtase_4Fe4S_dom. IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS. [Graphical view] |
| Gene3D | G3DSA:3.90.480.10. G3DSA:3.90.480.10. 2 hits. |
| KO | K00366. |
| Pfam | PF01077. NIR_SIR. 2 hits. PF03460. NIR_SIR_ferr. 2 hits. [Graphical view] |
| PRINTS | PR00397. SIROHAEM. |
| SUPFAM | SSF55124. NiR_SiRalpha_1/3. 2 hits. |
| PROSITE | PS00365. NIR_SIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SIR2_MYCPA | ||||||||
| Accession | Primary (citable) accession number: Q73XV0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with