Q73XR2 (PROA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	MAP_2247c

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_0000189752

Sequences

	Sequence		Length	Mass (Da)
	Q73XR2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6B809138D15EC5F3	FASTA	435	45,525
	10 20 30 40 50 60 MGLQAPFRSG GGTSRPQGRA APRAVDLRRE VHDAARRARV ASRVLALLPA VAKDQALRSA 70 80 90 100 110 120 ADAIAGHAEL ILSANAEDLE TARAAGTPSA MLDRLALDTK RVEGIAAGLR QVAGLPDPVG 130 140 150 160 170 180 EVLRGYTLPN GLQLRQQRVP LGVVGMIYEG RPNVTVDAFG LALKSGNAVL LRGSSSATRS 190 200 210 220 230 240 NQALVQVLRA SLVSEDLPAD AVQLLSADDR ATVTHLIQAR GLVDVVIPRG GANLINAVVR 250 260 270 280 290 300 DAQVPTIETG VGNCHVYVHE GADLEVAERV LLNSKTRRPS VCNAAETLLV DAAIAEEALP 310 320 330 340 350 360 RLVTALQDAG VTVHGGFARD ATEDDLRREY LSMDIAVAVV DGVDAAIAHI NEYGTGHTEA 370 380 390 400 410 420 IVTTNMAAAQ RFTDGVDAAA VMVNASTAFT DGEQFGFGAE IGISTQKLHA RGPMGLPELT 430 STKWIAWGDG QTRPA

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS04564.1.
RefSeq	NP_961181.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73XR2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038060; EBMYCP00000036449; EBMYCG00000038055.
GeneID	2718562.
GenomeReviews	Gene locus MAP_2247c in contig AE016958_GR.
KEGG	mpa:MAP2247c.
NMPDR	fig|262316.1.peg.2247.
PATRIC	17997132. VBIMycAvi108102_2390.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015663.
HOGENOM	HBG318080.
OMA	QYPAACN.
ProtClustDB	PRK00197.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_MYCPA

Accession

Primary (citable) accession number: Q73XR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program