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Q73X87 (RNPH_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease PH

Short name=RNase PH
EC=2.7.7.56
Alternative name(s):
tRNA nucleotidyltransferase
Gene names
Name:rph
Synonyms:rphA
Ordered Locus Names:MAP_2422c
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity. HAMAP-Rule MF_00564

Catalytic activity

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. HAMAP-Rule MF_00564

Sequence similarities

Belongs to the RNase PH family.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA nucleotidyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

tRNA-specific ribonuclease activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Ribonuclease PH HAMAP-Rule MF_00564
PRO_0000139911

Sequences

Sequence LengthMass (Da)Tools
Q73X87 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C836BF24308E39F6

FASTA25927,375
        10         20         30         40         50         60 
MTRREDGRLD DELRPLVITR GFTEHPAGSV LIEFGHTKVM CTASVTEGVP RWRKGSGLGW 

        70         80         90        100        110        120 
LTAEYAMLPS ATHTRSDRES VKGRLSGRTQ EISRLIGRSL RACIDLAALG ENTIAVDCDV 

       130        140        150        160        170        180 
LQADGGTRTA AITGAFVALA DAVTYLSAAG KLSDPRPLSC AIAAVSVGVV DGRIRVDLPY 

       190        200        210        220        230        240 
EEDARAEVDM NVVATDTGTL VEVQGTGEGA TFPRSTLDKL LDAALAACDK LFAAQREALK 

       250 
LPYPGVLPEG PPPPKAFGS 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS04739.1.
RefSeqNP_961356.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73X87.
SMRQ73X87. Positions 3-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP2422c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS04739; AAS04739; MAP_2422c.
GeneID2717627.
KEGGmpa:MAP2422c.
PATRIC17997510. VBIMycAvi108102_2573.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0689.
KOK00989.
OMAKGQGWVT.
OrthoDBEOG6CZQQP.
ProtClustDBPRK00173.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-2454-MONOMER.

Family and domain databases

Gene3D3.30.230.70. 1 hit.
HAMAPMF_00564. RNase_PH.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsTIGR01966. RNasePH. 1 hit.
PROSITEPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNPH_MYCPA
AccessionPrimary (citable) accession number: Q73X87
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families