Q73X40 (SYR_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	MAP_2470c

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000242045
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q73X40 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 91132E9C2E6EC665	FASTA	550	59,469
	10 20 30 40 50 60 MTPADLAELL RNTAAAVLAE RGLDAAALPA TVVVERPRNP EHGDYASNLA LQLGKKVGAN 70 80 90 100 110 120 PRELAGWLAA ALAETDGIAS AEVAGPGFIN LRLEASAQAV VVTNVLDAGD RYGHSDAQST 130 140 150 160 170 180 HNINLEFVSA NPTGPIHIGG TRWAAVGDAL GRLLSTQGAG VVREYYFNDH GAQIDRFASS 190 200 210 220 230 240 LIAAAKGEPT PEDGYAGSYI NDIAAQVLRQ APDALSLPEP QLRETFRAIG VDLMFTHIKE 250 260 270 280 290 300 SLHEFGTDFD VYTHEDSMHT SGRVDQAIAR LRETGNIYEK DGATWLRTSA FGDDKDRVVI 310 320 330 340 350 360 KSDGKPAYIA GDIAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAVAAAFG DDPATVEVLI 370 380 390 400 410 420 GQMVNLVRDG QPVRMSKRAG TVITLDDLVE AIGVDAARYS LIRSSVDTPI DIDLALWSSA 430 440 450 460 470 480 SNENPVYYVQ YAHARLSALA RNAAELGLIP DTAHLELLSH DKEGTLLRTL GEFPRVLKTA 490 500 510 520 530 540 ASLREPHRVC RYLEDLAGDY HRFYDSCRVL PQGDEQPTDL HTARLALCQA TRQVIANGLA 550 ILGVTAPERM

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS04787.1.
RefSeq	NP_961404.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73X40.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000039750; EBMYCP00000038139; EBMYCG00000039745.
GeneID	2718076.
GenomeReviews	Gene locus MAP_2470c in contig AE016958_GR.
KEGG	mpa:MAP2470c.
NMPDR	fig|262316.1.peg.2470.
PATRIC	17997612. VBIMycAvi108102_2621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016532.
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_MYCPA

Accession

Primary (citable) accession number: Q73X40

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program