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Q73X40 (SYR_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MAP_2470c
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242045

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q73X40 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 91132E9C2E6EC665

FASTA55059,469
        10         20         30         40         50         60 
MTPADLAELL RNTAAAVLAE RGLDAAALPA TVVVERPRNP EHGDYASNLA LQLGKKVGAN 

        70         80         90        100        110        120 
PRELAGWLAA ALAETDGIAS AEVAGPGFIN LRLEASAQAV VVTNVLDAGD RYGHSDAQST 

       130        140        150        160        170        180 
HNINLEFVSA NPTGPIHIGG TRWAAVGDAL GRLLSTQGAG VVREYYFNDH GAQIDRFASS 

       190        200        210        220        230        240 
LIAAAKGEPT PEDGYAGSYI NDIAAQVLRQ APDALSLPEP QLRETFRAIG VDLMFTHIKE 

       250        260        270        280        290        300 
SLHEFGTDFD VYTHEDSMHT SGRVDQAIAR LRETGNIYEK DGATWLRTSA FGDDKDRVVI 

       310        320        330        340        350        360 
KSDGKPAYIA GDIAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAVAAAFG DDPATVEVLI 

       370        380        390        400        410        420 
GQMVNLVRDG QPVRMSKRAG TVITLDDLVE AIGVDAARYS LIRSSVDTPI DIDLALWSSA 

       430        440        450        460        470        480 
SNENPVYYVQ YAHARLSALA RNAAELGLIP DTAHLELLSH DKEGTLLRTL GEFPRVLKTA 

       490        500        510        520        530        540 
ASLREPHRVC RYLEDLAGDY HRFYDSCRVL PQGDEQPTDL HTARLALCQA TRQVIANGLA 

       550 
ILGVTAPERM 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS04787.1.
RefSeqNP_961404.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73X40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP2470c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS04787; AAS04787; MAP_2470c.
GeneID2718076.
KEGGmpa:MAP2470c.
PATRIC17997612. VBIMycAvi108102_2621.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAQQEVFRS.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-2505-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCPA
AccessionPrimary (citable) accession number: Q73X40
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries