Q73WX4 (KGD_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate decarboxylase
EC=4.1.1.71

Alternative name(s):
2-oxoglutarate carboxy-lyase
Alpha-ketoglutarate decarboxylase

Gene names

Name:	kgd
Ordered Locus Names:	MAP_2536

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	1247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes an oxidative decarboxylation from five-carbon 2-oxoglutarate (alpha-ketoglutarate) to four-carbon succinate semialdehyde By similarity.
Catalytic activity	2-oxoglutarate = succinate semialdehyde + CO2.
Cofactor	Magnesium By similarity. Thiamine pyrophosphate By similarity.
Sequence similarities	Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Domain	Coiled coil
Ligand	Magnesium Thiamine pyrophosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-oxoglutarate decarboxylase activity Inferred from electronic annotation. Source: EC oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1247	1247	2-oxoglutarate decarboxylase		PRO_0000310717
Regions
	Coiled coil	803 – 833	31	Potential
	Compositional bias	51 – 129	79	Ala-rich

Sequences

	Sequence		Length	Mass (Da)
	Q73WX4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D31E9876D146519A	FASTA	1,247	137,073
	10 20 30 40 50 60 MSNISSPFGQ NEWLVEEMYR KFRDDPSSVD PSWHEFLVDY NPEPTGDSVL AAPASTDGPS 70 80 90 100 110 120 APAPAAPQTA QPALPAQTAP PAQTAQPARP APQPAAAPGN GASTRPAKPA TPPPAEGDEL 130 140 150 160 170 180 QTLRGAAAAV VKNMSASLEV PTATSVRAIP AKLLIDNRIV INNQLKRTRG GKISFTHLLG 190 200 210 220 230 240 YALVQAIKKF PNMNRHYAEI DGKPTAITPA HTNLGLAIDL QGKDGKRSLV VAGIKNCETM 250 260 270 280 290 300 RFAQFVTAYE DIVRRARDGK LTAEDFAGVT ISLTNPGTIG TVHSVPRLMN GQGAIIGVGA 310 320 330 340 350 360 MEYPAEFQGA SEERIAELGI GKLITLTSTY DHRIIQGAES GDFLRTIHEM LLSDGFWDDI 370 380 390 400 410 420 FRELSIPYLP IRWSTDNPDS IVDKNARVME LIAAYRNRGH LMADIDPLRL DGSRFRSHPD 430 440 450 460 470 480 LEILNHGLTL WDLDRVFKVN GFAGAEYKKL RDILGLLRDA YCRHIGVEYT HILDPEQQEW 490 500 510 520 530 540 LQQRVETKHV KPTVAEQKFI LSKLNAAEAF ETFLQTKYVG QKRFSLEGAE SVIPMMDAAI 550 560 570 580 590 600 DQCAEHGLDE VVIGMPHRGR LNVLANIVGK PYSQIFSEFE GNLNPAQAHG SGDVKYHLGA 610 620 630 640 650 660 TGVYLQMFGD NDIQVSLTAN PSHLEAVDPV LEGLVRAKQD LLDHGADDQG DEKAFSVVPM 670 680 690 700 710 720 MLHGDAAFAG QGVVAETLNL THLPGYRVGG TIHIIVNNQI GFTTAPEHSR SSEYCTDVAK 730 740 750 760 770 780 MIGAPIFHVN GDDPEACAWV AKLAVDFRQK FKKDVVIDML CYRKRGHNEG DDPSMTNPAM 790 800 810 820 830 840 YDVVDIKRGV RKSYTEALIG RGDISMKEAE DALRDYQGQL ERVFNEVREL EKHGVGPSES 850 860 870 880 890 900 VEADQMLPAG LATAVDKALL ARIGDAFLAL PEGFTAHPRV QPVLEKRREM AYEGKIDWAF 910 920 930 940 950 960 AELLALGSLV AGGKLVRLSG QDTRRGTFSQ RHSVIIDRNT GEEFTPLQLL ATNPDGTPTG 970 980 990 1000 1010 1020 GKFLVYDSPL SEYAAVGFEY GYTVGNPDAL VLWEAQFGDF VNGAQSIIDE FISSGEAKWG 1030 1040 1050 1060 1070 1080 QLSNVVLLLP HGHEGQGPDH TSARIERFLQ LWAEGSMTIA MPSTPSNYFH LLRRHALDGI 1090 1100 1110 1120 1130 1140 KRPLIVFTPK SMLRNKAAVS DIKDFTEIKF RSVLEEPTYE DGIGDRGKVS RVLLTSGKLY 1150 1160 1170 1180 1190 1200 YELVARKNKD NRDDVAIVRI EQLAPLPKRR LGETLDRYPN VREYFWVQEE PANQGAWPRF 1210 1220 1230 1240 GLELPELLPD KLTGLKRISR RAMSAPSSGS SKVHAVEQQE IIDTAFA

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS04853.1.
RefSeq	NP_961470.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73WX4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038281; EBMYCP00000036670; EBMYCG00000038276.
GeneID	2719042.
GenomeReviews	Gene locus MAP_2536 in contig AE016958_GR.
KEGG	mpa:MAP2536.
NMPDR	fig|262316.1.peg.2536.
PATRIC	17997756. VBIMycAvi108102_2692.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000014858.
HOGENOM	HBG289950.
OMA	EGDEPAF.
ProtClustDB	PRK12270.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
KO	K01616.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KGD_MYCPA

Accession

Primary (citable) accession number: Q73WX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program