Q73WG0 (COAA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	MAP_2700

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_1000043227
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q73WG0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2B8A90377A80A16C	FASTA	312	35,546
	10 20 30 40 50 60 MPRLSEPSPY VEFDRKQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATAEFLGE PQQNPDRPVP FVIGVAGSVA VGKSTTARVL QALLARWDHH 130 140 150 160 170 180 PRVDLVTTDG FLYPNAELDR RNLMHRKGFP ESYNRRALMR FVTSVKSGSD YACAPVYSHL 190 200 210 220 230 240 KYDIIPGAKH VVRHPDILIL EGLNVLQTGP TLMVSDLFDF GIYVDARIED IEQWYISRFL 250 260 270 280 290 300 AMRSTAFADP ESHFHHYAAL NDTKAVAAAR EIWRSINRPN LVENILPTRP RATLVLRKDA 310 DHSINRLRLR KL

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS05017.1.
RefSeq	NP_961634.1. NC_002944.2.
3D structure databases
HSSP	HSSP built from PDB template 1ESM based on UniProtKB P0A6I3.
ProteinModelPortal	Q73WG0.
SMR	Q73WG0. Positions 5-312.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038773; EBMYCP00000037162; EBMYCG00000038768.
GeneID	2719935.
GenomeReviews	Gene locus MAP_2700 in contig AE016958_GR.
KEGG	mpa:MAP2700.
NMPDR	fig|262316.1.peg.2700.
PATRIC	17998108. VBIMycAvi108102_2868.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCPA

Accession

Primary (citable) accession number: Q73WG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program