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Q73W61 (DCUP_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:MAP_2799c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325665

Regions

Region34 – 385Substrate binding By similarity

Sites

Binding site831Substrate By similarity
Binding site1581Substrate By similarity
Binding site2131Substrate By similarity
Binding site3361Substrate By similarity
Site831Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73W61 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D716FCF608A089CA

FASTA35737,894
        10         20         30         40         50         60 
MNSSARTRRD LPESPYLAAV NGRKPHRVPV WFMRQAGRSL PEYRALRAQH DMLSACFDAE 

        70         80         90        100        110        120 
LVCEITLQPV RRHDVDAAIL FSDIVVPLLG AGIDLDIVAG VGPVIASPVR TAADVAAMKP 

       130        140        150        160        170        180 
LERQRVQPIA DAVRLLVSAL VEVPLIGFAG APFTLASYLI EGGPSRHHAR TKAMMLADPD 

       190        200        210        220        230        240 
SWHALMEKLT DITVGFLRVQ LDAGVDAVQV FDSWAGALSL ANYRSYVQPH SARVFAALAD 

       250        260        270        280        290        300 
YGVPMTHFGV GTAELLGAMS AALKPAPATV VGVDWRTALA DAATRVMPGT ALQGNLDPVV 

       310        320        330        340        350 
LLAGWPVVET AARAVVDDGR RAVDAGAAGH VFNLGHGVLP ETDPGVLTEL VSLVHSL

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS05116.1.
RefSeqNP_961733.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1R3S based on UniProtKB P06132.
ProteinModelPortalQ73W61.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000037841; EBMYCP00000036230; EBMYCG00000037836.
GeneID2719865.
GenomeReviewsGene locus MAP_2799c in contig AE016958_GR.
KEGGmpa:MAP2799c.
NMPDRfig|262316.1.peg.2799.
PATRIC17998310. VBIMycAvi108102_2965.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016469.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_MYCPA
AccessionPrimary (citable) accession number: Q73W61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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