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Q73VZ7 (DAPA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:MAP_2864c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Dihydrodipicolinate synthase HAMAP MF_00418
PRO_1000124051

Regions

Region58 – 592Pyruvate binding By similarity

Sites

Active site1711Schiff-base intermediate with substrate By similarity
Binding site1161Pyruvate By similarity
Site1431Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73VZ7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1FF315C2BAF953CC

FASTA30030,973
        10         20         30         40         50         60 
MSTVGFDAPA RLGTVLTAMV TPFAADGSLD TAAAARLANH LVDSGCDGLV VSGTTGESPT 

        70         80         90        100        110        120 
TTDDEKRELL RVVLEAVGDR ARVIAGAGTY DTAHSVRLAK ACAAEGAHGL LVVTPYYSKP 

       130        140        150        160        170        180 
PQRGLIAHFT AVADATELPV LLYDIPGRSV VPIESSTIRA LASHPNIVGV KDAKADLHAG 

       190        200        210        220        230        240 
GQIIAETGLA YYSGDDALNL PWLAMGATGF ISVISHVAAN QLRELLSAFT SGDIATARKI 

       250        260        270        280        290        300 
NATVTPLCDA MARLGGVTMS KAGLRLQGID VGDPRLPQVP ATPEQIEALT ADMRAASVLR

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS05181.1.
RefSeqNP_961798.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1XXX based on UniProtKB P63945.
ProteinModelPortalQ73VZ7.
SMRQ73VZ7. Positions 5-300.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000038351; EBMYCP00000036740; EBMYCG00000038346.
GeneID2721019.
GenomeReviewsGene locus MAP_2864c in contig AE016958_GR.
KEGGmpa:MAP2864c.
NMPDRfig|262316.1.peg.2864.
PATRIC17998448. VBIMycAvi108102_3034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016215.
HOGENOMHBG358848.
OMARTDLAYY.
ProtClustDBPRK03170.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_MYCPA
AccessionPrimary (citable) accession number: Q73VZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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