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Q73VU0 (MQO_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:MAP_2921c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Probable malate:quinone oxidoreductase HAMAP MF_00212
PRO_0000325500

Sequences

Sequence LengthMass (Da)Tools
Q73VU0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A2BBF534427F4B5E

FASTA50154,937
        10         20         30         40         50         60 
MSSLARTTRA DVVLVGAGIM SATLGALLRR LQPDWSMTFV ERLDAVAAES SSPWNNAGTG 

        70         80         90        100        110        120 
HSALCELNYT PQRADGSIDI AKAVRINEQF QVTRQFWAYA VENGMLTDRG FVTPIPHASF 

       130        140        150        160        170        180 
VRGARAVEYL RRRQQALAPN PLFAGIELIE DADEFARRLP LMADRRDFSE PTALNWARHG 

       190        200        210        220        230        240 
TDVDFGALSR QLIGFCVRGG ATALFGHQVH NLTRESDGSW TLLIRNRRTG EKHWCNAKFV 

       250        260        270        280        290        300 
LVGAGGDALP LLQKSGIGEA RGFAGFPIGG RFLRADNPVL TEAHRAKVYG APAPGAPPLG 

       310        320        330        340        350        360 
ALHLDLRYVN GKPWLVFGPY AGWSPKFLKH GHFTDLPRSV RPHNLVALLG VGVTQLTLLR 

       370        380        390        400        410        420 
YLIGQLRLSA PDRMRMLREF APTAVDSDWE LTVAGQRVQV IRRDRRRGGV LDFDTTVVAA 

       430        440        450        460        470        480 
GDGSIAGLLG GSPGASTAVP IMLDVLQRCF ADRYRSWLPA LKEMVPSLGV TLSDEPALYE 

       490        500 
EVYSWGTKIL GLDELDEERP K

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS05238.1.
RefSeqNP_961855.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73VU0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000037273; EBMYCP00000035662; EBMYCG00000037268.
GeneID2721811.
GenomeReviewsGene locus MAP_2921c in contig AE016958_GR.
KEGGmpa:MAP2921c.
NMPDRfig|262316.1.peg.2921.
PATRIC17998572. VBIMycAvi108102_3096.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015585.
HOGENOMHBG289663.
OMAKKWVPLM.
ProtClustDBPRK05257.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO_MYCPA
AccessionPrimary (citable) accession number: Q73VU0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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