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Q73VC3 (COX1_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Ordered Locus Names:MAP_3091c
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 copper B per subunit By similarity.

Binds 2 heme groups per subunit By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subunit structure

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 581581Probable cytochrome c oxidase subunit 1
PRO_0000183442

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane359 – 37921Helical; Potential
Transmembrane398 – 41821Helical; Potential
Transmembrane433 – 45321Helical; Potential
Transmembrane476 – 49621Helical; Potential

Sites

Metal binding861Iron (heme A axial ligand) By similarity
Metal binding2641Copper B By similarity
Metal binding2681Copper B By similarity
Metal binding3131Copper B By similarity
Metal binding3141Copper B By similarity
Metal binding3971Iron (heme A3 axial ligand) By similarity
Metal binding3991Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73VC3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 44070A2199FA6E0A

FASTA58164,577
        10         20         30         40         50         60 
MTAEAPPLGE LEAVRPYPDR TGPKGNLVYK LITTTDHKMI GIMYTVTCFA FFFIGGLMAL 

        70         80         90        100        110        120 
LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLLYATPVVF GFANLVLPLQ IGAPDVAFPR 

       130        140        150        160        170        180 
LNAFSFWLFL FGGLIAASGF IVPGGAADFG WTAYTPLSDA VHSPGAGGDL WITGLIVAGL 

       190        200        210        220        230        240 
GTILGAVNMI TTVVCMRAPG MTMFRMPIFT WNILVTSILI LIAFPILTAA LFGLAADRHL 

       250        260        270        280        290        300 
GAHVYDAANG GVLLWQHLFW FFGHPEVYII ALPFFGIITE IIPVFARKPV FGYTTLVYAT 

       310        320        330        340        350        360 
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK GQLTFETPML 

       370        380        390        400        410        420 
FCVGFLLTFL LGGLTGVMLA SPPLDFHVTD TYFVVAHFHY VLFGTIVFAT FAGVYFWFPK 

       430        440        450        460        470        480 
MTGRLLDERL GKLHFWLTFI GFHTTFLVQH WLGDLGMPRR YADYLPSDGF QPYNVASTVG 

       490        500        510        520        530        540 
AFILGASMFP FVWNVFKSWR YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER 

       550        560        570        580 
PAFELHYPHM VERLRAEAHV GRAHGPADKD VTRLDDVQVR S 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS05639.1.
RefSeqNP_962025.1. NC_002944.2.

3D structure databases

ProteinModelPortalQ73VC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP3091c.

Proteomic databases

PRIDEQ73VC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS05639; AAS05639; MAP_3091c.
GeneID2718055.
KEGGmpa:MAP3091c.
PATRIC17998936. VBIMycAvi108102_3276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0843.
KOK02274.
OMAIGANESH.
OrthoDBEOG6B35XR.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-3133-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_MYCPA
AccessionPrimary (citable) accession number: Q73VC3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways