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Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathway:ioxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron (heme A axial ligand)By similarity
Metal bindingi264 – 2641Copper BBy similarity
Metal bindingi268 – 2681Copper BBy similarity
Metal bindingi313 – 3131Copper BBy similarity
Metal bindingi314 – 3141Copper BBy similarity
Metal bindingi397 – 3971Iron (heme A3 axial ligand)By similarity
Metal bindingi399 – 3991Iron (heme A axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-3133-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:MAP_3091c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence AnalysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Probable cytochrome c oxidase subunit 1PRO_0000183442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiQ73VC3.

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi262316.MAP3091c.

Structurei

3D structure databases

ProteinModelPortaliQ73VC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiWSPAMLW.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73VC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEAPPLGE LEAVRPYPDR TGPKGNLVYK LITTTDHKMI GIMYTVTCFA
60 70 80 90 100
FFFIGGLMAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLLYATPVVF
110 120 130 140 150
GFANLVLPLQ IGAPDVAFPR LNAFSFWLFL FGGLIAASGF IVPGGAADFG
160 170 180 190 200
WTAYTPLSDA VHSPGAGGDL WITGLIVAGL GTILGAVNMI TTVVCMRAPG
210 220 230 240 250
MTMFRMPIFT WNILVTSILI LIAFPILTAA LFGLAADRHL GAHVYDAANG
260 270 280 290 300
GVLLWQHLFW FFGHPEVYII ALPFFGIITE IIPVFARKPV FGYTTLVYAT
310 320 330 340 350
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK
360 370 380 390 400
GQLTFETPML FCVGFLLTFL LGGLTGVMLA SPPLDFHVTD TYFVVAHFHY
410 420 430 440 450
VLFGTIVFAT FAGVYFWFPK MTGRLLDERL GKLHFWLTFI GFHTTFLVQH
460 470 480 490 500
WLGDLGMPRR YADYLPSDGF QPYNVASTVG AFILGASMFP FVWNVFKSWR
510 520 530 540 550
YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM
560 570 580
VERLRAEAHV GRAHGPADKD VTRLDDVQVR S
Length:581
Mass (Da):64,577
Last modified:July 5, 2004 - v1
Checksum:i44070A2199FA6E0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS05639.1.
RefSeqiWP_003878775.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS05639; AAS05639; MAP_3091c.
GeneIDi2718055.
KEGGimpa:MAP3091c.
PATRICi17998936. VBIMycAvi108102_3276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS05639.1.
RefSeqiWP_003878775.1. NC_002944.2.

3D structure databases

ProteinModelPortaliQ73VC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP3091c.

Proteomic databases

PRIDEiQ73VC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS05639; AAS05639; MAP_3091c.
GeneIDi2718055.
KEGGimpa:MAP3091c.
PATRICi17998936. VBIMycAvi108102_3276.

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiWSPAMLW.
OrthoDBiEOG6B35XR.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciMAVI262316:GCQR-3133-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiCOX1_MYCPA
AccessioniPrimary (citable) accession number: Q73VC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.