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Q73VC3

- COX1_MYCPA

UniProt

Q73VC3 - COX1_MYCPA

Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B per subunit.By similarity
    Binds 2 heme groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Iron (heme A axial ligand)By similarity
    Metal bindingi264 – 2641Copper BBy similarity
    Metal bindingi268 – 2681Copper BBy similarity
    Metal bindingi313 – 3131Copper BBy similarity
    Metal bindingi314 – 3141Copper BBy similarity
    Metal bindingi397 – 3971Iron (heme A3 axial ligand)By similarity
    Metal bindingi399 – 3991Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-3133-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    Ordered Locus Names:MAP_3091c
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Probable cytochrome c oxidase subunit 1PRO_0000183442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Proteomic databases

    PRIDEiQ73VC3.

    Interactioni

    Subunit structurei

    Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi262316.MAP3091c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73VC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei476 – 49621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    KOiK02274.
    OMAiIGANESH.
    OrthoDBiEOG6B35XR.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73VC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAEAPPLGE LEAVRPYPDR TGPKGNLVYK LITTTDHKMI GIMYTVTCFA    50
    FFFIGGLMAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLLYATPVVF 100
    GFANLVLPLQ IGAPDVAFPR LNAFSFWLFL FGGLIAASGF IVPGGAADFG 150
    WTAYTPLSDA VHSPGAGGDL WITGLIVAGL GTILGAVNMI TTVVCMRAPG 200
    MTMFRMPIFT WNILVTSILI LIAFPILTAA LFGLAADRHL GAHVYDAANG 250
    GVLLWQHLFW FFGHPEVYII ALPFFGIITE IIPVFARKPV FGYTTLVYAT 300
    LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK 350
    GQLTFETPML FCVGFLLTFL LGGLTGVMLA SPPLDFHVTD TYFVVAHFHY 400
    VLFGTIVFAT FAGVYFWFPK MTGRLLDERL GKLHFWLTFI GFHTTFLVQH 450
    WLGDLGMPRR YADYLPSDGF QPYNVASTVG AFILGASMFP FVWNVFKSWR 500
    YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM 550
    VERLRAEAHV GRAHGPADKD VTRLDDVQVR S 581
    Length:581
    Mass (Da):64,577
    Last modified:July 5, 2004 - v1
    Checksum:i44070A2199FA6E0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS05639.1.
    RefSeqiNP_962025.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS05639; AAS05639; MAP_3091c.
    GeneIDi2718055.
    KEGGimpa:MAP3091c.
    PATRICi17998936. VBIMycAvi108102_3276.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS05639.1 .
    RefSeqi NP_962025.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q73VC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP3091c.

    Proteomic databases

    PRIDEi Q73VC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS05639 ; AAS05639 ; MAP_3091c .
    GeneIDi 2718055.
    KEGGi mpa:MAP3091c.
    PATRICi 17998936. VBIMycAvi108102_3276.

    Phylogenomic databases

    eggNOGi COG0843.
    KOi K02274.
    OMAi IGANESH.
    OrthoDBi EOG6B35XR.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci MAVI262316:GCQR-3133-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiCOX1_MYCPA
    AccessioniPrimary (citable) accession number: Q73VC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3