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Q73VC3

- COX1_MYCPA

UniProt

Q73VC3 - COX1_MYCPA

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Protein

Probable cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit.By similarity
Binds 2 heme groups per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron (heme A axial ligand)By similarity
Metal bindingi264 – 2641Copper BBy similarity
Metal bindingi268 – 2681Copper BBy similarity
Metal bindingi313 – 3131Copper BBy similarity
Metal bindingi314 – 3141Copper BBy similarity
Metal bindingi397 – 3971Iron (heme A3 axial ligand)By similarity
Metal bindingi399 – 3991Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-3133-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:MAP_3091c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Probable cytochrome c oxidase subunit 1PRO_0000183442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiQ73VC3.

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi262316.MAP3091c.

Structurei

3D structure databases

ProteinModelPortaliQ73VC3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence AnalysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiIGANESH.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73VC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAEAPPLGE LEAVRPYPDR TGPKGNLVYK LITTTDHKMI GIMYTVTCFA
60 70 80 90 100
FFFIGGLMAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLLYATPVVF
110 120 130 140 150
GFANLVLPLQ IGAPDVAFPR LNAFSFWLFL FGGLIAASGF IVPGGAADFG
160 170 180 190 200
WTAYTPLSDA VHSPGAGGDL WITGLIVAGL GTILGAVNMI TTVVCMRAPG
210 220 230 240 250
MTMFRMPIFT WNILVTSILI LIAFPILTAA LFGLAADRHL GAHVYDAANG
260 270 280 290 300
GVLLWQHLFW FFGHPEVYII ALPFFGIITE IIPVFARKPV FGYTTLVYAT
310 320 330 340 350
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWIGTMWK
360 370 380 390 400
GQLTFETPML FCVGFLLTFL LGGLTGVMLA SPPLDFHVTD TYFVVAHFHY
410 420 430 440 450
VLFGTIVFAT FAGVYFWFPK MTGRLLDERL GKLHFWLTFI GFHTTFLVQH
460 470 480 490 500
WLGDLGMPRR YADYLPSDGF QPYNVASTVG AFILGASMFP FVWNVFKSWR
510 520 530 540 550
YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM
560 570 580
VERLRAEAHV GRAHGPADKD VTRLDDVQVR S
Length:581
Mass (Da):64,577
Last modified:July 5, 2004 - v1
Checksum:i44070A2199FA6E0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS05639.1.
RefSeqiNP_962025.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS05639; AAS05639; MAP_3091c.
GeneIDi2718055.
KEGGimpa:MAP3091c.
PATRICi17998936. VBIMycAvi108102_3276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS05639.1 .
RefSeqi NP_962025.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73VC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP3091c.

Proteomic databases

PRIDEi Q73VC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS05639 ; AAS05639 ; MAP_3091c .
GeneIDi 2718055.
KEGGi mpa:MAP3091c.
PATRICi 17998936. VBIMycAvi108102_3276.

Phylogenomic databases

eggNOGi COG0843.
KOi K02274.
OMAi IGANESH.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci MAVI262316:GCQR-3133-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiCOX1_MYCPA
AccessioniPrimary (citable) accession number: Q73VC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3