ID   Q73UL4_MYCPA            Unreviewed;       523 AA.
AC   Q73UL4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   RecName: Full=LuxR family transcriptional regulator {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=MAP_3352c {ECO:0000313|EMBL:AAS05902.1};
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS05902.1, ECO:0000313|Proteomes:UP000000580};
RN   [1] {ECO:0000313|EMBL:AAS05902.1, ECO:0000313|Proteomes:UP000000580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
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DR   EMBL; AE016958; AAS05902.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q73UL4; -.
DR   STRING; 262316.MAP_3352c; -.
DR   KEGG; mpa:MAP_3352c; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 2.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR   PROSITE; PS51832; HD_GYP; 2.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT   DOMAIN          27..242
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          257..453
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          449..514
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   523 AA;  56185 MW;  E7A62D1DEDD124A1 CRC64;
     MMLMAQAVLP TRAELLAALS VAIDLGLGQP AEHMLRAALI ATRLCDRLGL SRQQRDCVYY
     TTLVMWIGCH ADSHEYARWF GDDIAVRHDS YLVDWSGIPY LRFLASNVGR GQPLAHRLSV
     MATLFANARG HISRLIHSHC ASAALLADRI GLGPNVQAAL AYTFERYDGG GLPTGARGED
     IPIQMRIAQL ADMVEVHHRS YGVAGAVAMV GARRGGQFDP GIADVFLRDA DAILAGPQTG
     DAWAAALREA PDRHRVDEQS LDAALVALGD FVDLKCPFTL GHSRAVARLA GQAARAAGLD
     ADAVALTRRA GHVHDLGRIG VSNQIWSRPG PLSGSQFERV RLHPYLTVRI LDQVPGLRRL
     AEVAGNHHEC LDGSGYPRGL AGPALGMPDR ILAAAVCYQS GREPRPYREQ LSEAEAARRL
     RGRVRCGELD PVAAEAVLHA AGQPVGPRPN PRPDGLTPRE IEVLGHVARG ASNKEIAAAL
     VISEKTARNH VERTYAKIGV SNRIGASMYA LQHGLVPAAP LHS
//