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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Binding sitei249SubstrateUniRule annotation1
Binding sitei253SubstrateUniRule annotation1
Binding sitei254NADUniRule annotation1
Binding sitei306NADUniRule annotation1
Binding sitei341NADUniRule annotation1
Binding sitei410NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 222NADUniRule annotation3
Nucleotide bindingi283 – 288NADUniRule annotation6
Nucleotide bindingi362 – 364NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Synonyms:sahH
Ordered Locus Names:MAP_3362c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169701 – 496AdenosylhomocysteinaseAdd BLAST496

Proteomic databases

PRIDEiQ73UK6.

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3362c.

Structurei

3D structure databases

ProteinModelPortaliQ73UK6.
SMRiQ73UK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73UK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTENALTP DVRNGIEFKV ADLSLADYGR RDIELSEQEM PGLMSLRREY
60 70 80 90 100
HDVQPLKGAR ISGSLHMTVQ TAVLIETLVA LGAEVRWASC NIFSTQDHAA
110 120 130 140 150
AAVVVGPHGT PEEPRGVPVF AWKGETLEEY WWAAEQALTW PPLADGTEAP
160 170 180 190 200
ANMILDDGGD ATMLVLRGAQ YEKAGVVPPD DEDDSAEHRV FLNLLRARFE
210 220 230 240 250
TDKTKWTKIS ESIKGVTEET TTGVLRLYQF AAAGDLAFPA INVNDSVTKS
260 270 280 290 300
KFDNKYGCRH SLIDGINRGT DVLIGGKNVL VCGYGDVGKG SVESLAGQGA
310 320 330 340 350
RVTVTEIDPI NALQALMEGY NVKRVEDVIG EADIVITATG NKDIITLEHM
360 370 380 390 400
KAMKDKAILG NIGHFDNEIQ IARLEKSGAI KTNIRPQVDL WTFPDTGKSI
410 420 430 440 450
IVLSEGRLLN LGNATGHPSF VMSNSFSNQV IAQIELWTKN DEYDNEVYRL
460 470 480 490
PKHLDEKVAR IHVEALGGEL TKLTKEQAEY IGVDVDGPYK ADHYRY
Length:496
Mass (Da):54,435
Last modified:July 5, 2004 - v1
Checksum:i5BAAC3DBA52F6BBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS05912.1.
RefSeqiWP_003878944.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS05912; AAS05912; MAP_3362c.
GeneIDi2719309.
KEGGimpa:MAP_3362c.
PATRICifig|262316.17.peg.3574.

Similar proteinsi

Entry informationi

Entry nameiSAHH_MYCPA
AccessioniPrimary (citable) accession number: Q73UK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families