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Q73UD0 (ADD_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:MAP_3438c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Adenosine deaminase HAMAP MF_00540
PRO_1000017669

Sites

Active site2111Proton donor By similarity
Metal binding191Zinc; catalytic By similarity
Metal binding211Zinc; catalytic By similarity
Metal binding2081Zinc; catalytic By similarity
Metal binding3041Zinc; catalytic By similarity
Binding site211Substrate By similarity
Binding site231Substrate By similarity
Binding site1811Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2321Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73UD0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 80EC045E97F13E55

FASTA36640,534
        10         20         30         40         50         60 
MTAPLELEQI RKAPKALLHD HLDGGLRPST VLDIAGQTGY DGLPATDVEE LATWFRTRSH 

        70         80         90        100        110        120 
SGSLERYLEP FSHTVAVMQT PEALHRVAYE CVEDLAEDSV VYAEIRFAPE LHINRGMSFD 

       130        140        150        160        170        180 
EIVDAVLAGF ADGEKACAAA GRPIVVRLLV TAMRHAAVSR EIAELAIRWR DKGVVGFDIA 

       190        200        210        220        230        240 
GAEAGNPPTR HLEAFDYMRD HNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI 

       250        260        270        280        290        300 
DVLADGPDKG KVRLGRLANI LRDKRIPLEL CPSSNVQTGA VKSIADHPFD LLARTRFRVT 

       310        320        330        340        350        360 
VNTDNRLMSD TYMSREMHRL VQAFGYGWSD LERFTINAMK SAFIPFDERL AIIDEVIKPR 


YAVLIG

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References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS05988.1.
RefSeqNP_962372.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1A4M based on UniProtKB P03958.
ProteinModelPortalQ73UD0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000038169; EBMYCP00000036558; EBMYCG00000038164.
GeneID2719405.
GenomeReviewsGene locus MAP_3438c in contig AE016958_GR.
KEGGmpa:MAP3438c.
NMPDRfig|262316.1.peg.3438.
PATRIC17999693. VBIMycAvi108102_3653.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016615.
HOGENOMHBG630382.
OMAPYYMAMN.
ProtClustDBPRK09358.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_MYCPA
AccessionPrimary (citable) accession number: Q73UD0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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