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Protein

Homoserine O-acetyltransferase

Gene

metXA

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metXA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157NucleophileUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Active sitei320UniRule annotation1
Active sitei350UniRule annotation1
Binding sitei351SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciMAVI262316:G1G0E-3627-MONOMER
UniPathwayiUPA00051; UER00074

Protein family/group databases

ESTHERimycpa-q73ub0 Homoserine_transacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXAUniRule annotation
Ordered Locus Names:MAP_3458
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557301 – 392Homoserine O-acetyltransferaseAdd BLAST392

Proteomic databases

PRIDEiQ73UB0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262316.MAP3458

Structurei

3D structure databases

ProteinModelPortaliQ73UB0
SMRiQ73UB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 356AB hydrolase-1UniRule annotationAdd BLAST305

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV Bacteria
COG2021 LUCA
KOiK00641
OMAiCQGTTGP
OrthoDBiPOG091H08NY

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
HAMAPiMF_00296 MetX_acyltransf, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR008220 HAT_MetX-like
PANTHERiPTHR32268 PTHR32268, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000443 Homoser_Ac_trans, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01392 homoserO_Ac_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q73UB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPDVPTQT LPDEGEIGFV HIGSLTTEAG AVIDDVHIAV QRWGELSPTR
60 70 80 90 100
DNVVVVLHAL TGDSHVTGPA GPGHPTGGWW DEMVGPGAPI DTDRWCAVAT
110 120 130 140 150
NVLGGCRGST GPSSRTRDGK PWGSRFPRIS IRDQVEADIA ALAALGIDEV
160 170 180 190 200
AAVVGGSMGG ARALEWIVGH PSRVRAGLLL AVGARATADQ IGTQCTQIAA
210 220 230 240 250
IKSDPNWQGG DYHDTGRTPD AGLAIARRFA HLTYRGEVEL DTRFGNDAQL
260 270 280 290 300
DEDPANSGRY AVQSYLEYQG VKLVERFDAG SYVVLTEALN SHDVGRARGG
310 320 330 340 350
VRKALRSCPV PVVVGGITSD RLYPLRLQQE LAEQLPGCAE LQVVDSICGH
360 370 380 390
DGFLVESEAV GEMIRKTLLL AGSQSAGPGG AGPGSRKGTT RR
Length:392
Mass (Da):41,244
Last modified:July 5, 2004 - v1
Checksum:iE63E8BA1AED0A911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS06008.1
RefSeqiWP_003874462.1, NC_002944.2

Genome annotation databases

EnsemblBacteriaiAAS06008; AAS06008; MAP_3458
GeneIDi2720909
KEGGimpa:MAP_3458

Similar proteinsi

Entry informationi

Entry nameiMETXA_MYCPA
AccessioniPrimary (citable) accession number: Q73UB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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