Q73U14 (MSRA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	MAP_3554c

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000068343
Sites
	Active site	13	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73U14 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F9B34912601C4BF5	FASTA	171	19,316
	10 20 30 40 50 60 MTNTQKAILA GGCFWGMQEL IRKQPGVVST RVGYTGGDVP NATYRNHGTH AEAVEIIYDP 70 80 90 100 110 120 AVTDYRQILE FFFQIHDPTT KDRQGNDRGP SYRSAIFYTD DEQKRIALDT IADVEASGLW 130 140 150 160 170 PGKVVTEVSP AGDFWEAEPE HQDYLQRYPN GYTCHYIRPG WKLPRRATSG S

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS06104.1.
RefSeq	NP_962488.1. NC_002944.2.
3D structure databases
HSSP	HSSP built from PDB template 1NWA based on UniProtKB P0A5L0.
ProteinModelPortal	Q73U14.
SMR	Q73U14. Positions 1-166.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000036693; EBMYCP00000035082; EBMYCG00000036688.
GeneID	2718952.
GenomeReviews	Gene locus MAP_3554c in contig AE016958_GR.
KEGG	mpa:MAP3554c.
NMPDR	fig|262316.1.peg.3554.
PATRIC	17999955. VBIMycAvi108102_3784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017224.
HOGENOM	HBG748152.
OMA	YRQILEF.
ProtClustDB	PRK14054.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_MYCPA

Accession

Primary (citable) accession number: Q73U14

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program