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Q73TS5

- TRMB_MYCPA

UniProt

Q73TS5 - TRMB_MYCPA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, MAP_3643c
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Active sitei166 – 1661 By similarity
Binding sitei166 – 1661S-adenosyl-L-methionine By similarity
Binding sitei170 – 1701Substrate By similarity
Binding sitei202 – 2021Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-3687-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MAP_3643c
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171357Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3643c.

Structurei

3D structure databases

ProteinModelPortaliQ73TS5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 2414Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiLHIATDH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73TS5-1 [UniParc]FASTAAdd to Basket

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MGHHGQMHAQ HGVTMPADSP IGQPDRSEQR YFPATAFRTR RSTLSDAQRQ    50
TWDRRWPELG LSVGPAEDPD RPGPPLDTDA WFGRKAPVVL EIGCGNGTST 100
LAMAKEEPGV DVIAVEVYRR GLAQLLCAID RDNVTNIRLI RGNALDVLQR 150
LIAPASLTGV RVFFPDPWPK ARHHKRRFLQ PGTVGLIADR LLPGGVLHVA 200
TDHAGYAEHI ADVGAGEPRL RPANPDSPLP ISVARPTTKY ETKAQDAGSA 250
VTEFIWLRR 259
Length:259
Mass (Da):28,411
Last modified:July 5, 2004 - v1
Checksum:i5DDA5DFA345BE461
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS06193.1.
RefSeqiNP_962577.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS06193; AAS06193; MAP_3643c.
GeneIDi2719251.
KEGGimpa:MAP3643c.
PATRICi18000131. VBIMycAvi108102_3872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS06193.1 .
RefSeqi NP_962577.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73TS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP3643c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS06193 ; AAS06193 ; MAP_3643c .
GeneIDi 2719251.
KEGGi mpa:MAP3643c.
PATRICi 18000131. VBIMycAvi108102_3872.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi LHIATDH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MAVI262316:GCQR-3687-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiTRMB_MYCPA
AccessioniPrimary (citable) accession number: Q73TS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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