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Q73TP5 (GABD1_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate-semialdehyde dehydrogenase [NADP+]
Short name=SSADH
Short name=SSDH
EC=1.2.1.79
Gene names
Name:gabD1
Ordered Locus Names:MAP_3673c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310704

Regions

Nucleotide binding134 – 1352NADP By similarity
Nucleotide binding158 – 1614NADP By similarity
Nucleotide binding210 – 2112NADP By similarity

Sites

Active site2321Proton acceptor By similarity
Active site2661Nucleophile By similarity
Binding site2331NADP; via carbonyl oxygen By similarity
Binding site3631NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73TP5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 64B882C6A0A489BC

FASTA47249,980
        10         20         30         40         50         60 
MPIATINPAT GETVKTFTPA SDAEVDAAIA RAYERFLDYR HSTTFAQRAQ WANATADLLE 

        70         80         90        100        110        120 
AEADEVAAMM TLEMGKTLKS AKAEALKCAK GFRYYAQNAE QLLADEPADA GKVGAARAYI 

       130        140        150        160        170        180 
RYQPLGVVLA VMPWNFPLWQ AVRFAAPALM AGNVGILKHA SNVPQSALYL ADVITRGGFP 

       190        200        210        220        230        240 
EGCFQTLLVP SSAVERILRD PRVAAATLTG SEPAGQSVAA IAGDEIKPTV LELGGSDPFI 

       250        260        270        280        290        300 
VMPSADLDEA VKTAVTARVQ NNGQSCIAAK RFIVHTDIYD AFVDKFVEQM KALKVGDPTD 

       310        320        330        340        350        360 
PATDVGPLAT ESGRDEIAKQ VDDAVAAGAT LRCGGKPLDG PGWFYPPTVV TDITKDMALY 

       370        380        390        400        410        420 
TEEVFGPVAS MYRAADIDEA IEIANATTFG LGSNAWTNDA AEQQRFIDDI EAGQVFINGM 

       430        440        450        460        470 
TVSYPELGFG GVKRSGYGRE LAGLGIRAFC NAKTVWIGSS KSGDAGGGSK VE

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS06223.1.
RefSeqNP_962607.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1ZUM based on UniProtKB P05091.
ProteinModelPortalQ73TP5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000040291; EBMYCP00000038680; EBMYCG00000040286.
GeneID2719126.
GenomeReviewsGene locus MAP_3673c in contig AE016958_GR.
KEGGmpa:MAP3673c.
NMPDRfig|262316.1.peg.3673.
PATRIC18000201. VBIMycAvi108102_3907.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015659.
HOGENOMHBG752218.
OMAVPQSALY.
ProtClustDBPRK09406.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD1_MYCPA
AccessionPrimary (citable) accession number: Q73TP5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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