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Protein

Putative glutamate--cysteine ligase 2

Gene

MAP_3922

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamate--cysteine ligase 2UniRule annotation (EC:6.3.2.2UniRule annotation)
Alternative name(s):
Gamma-glutamylcysteine synthetase 2UniRule annotation
Short name:
GCS 2UniRule annotation
Short name:
Gamma-GCS 2UniRule annotation
Gene namesi
Ordered Locus Names:MAP_3922
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182071 – 376Putative glutamate--cysteine ligase 2Add BLAST376

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3922

Structurei

3D structure databases

ProteinModelPortaliQ73T00
SMRiQ73T00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106KXD Bacteria
COG2170 LUCA
KOiK06048
OMAiLDENKWR
OrthoDBiPOG091H09O7

Family and domain databases

HAMAPiMF_01609 Glu_cys_ligase_2, 1 hit
InterProiView protein in InterPro
IPR006336 GCS2
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR011793 YbdK
PfamiView protein in Pfam
PF04107 GCS2, 1 hit
SUPFAMiSSF55931 SSF55931, 1 hit
TIGRFAMsiTIGR02050 gshA_cyan_rel, 1 hit

Sequencei

Sequence statusi: Complete.

Q73T00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARRGDAHI DFARSPRPTI GVEWEFALVD AQTRDLSNEA TAVIAEIGEN
60 70 80 90 100
PRVHKELLRN TVEVVSGICR TVPEAMEDLR QTLGPARRIV RDRGMELFCA
110 120 130 140 150
GAHPFAQWTT QKLTDAPRYA ELIKRTQWWG RQMLIWGVHV HVGISSPNKV
160 170 180 190 200
MPIMTSLLNY YPHLLALSAS SPWWTGVDTG YASNRAMMFQ QLPTAGLPFQ
210 220 230 240 250
FQTWAEFEGF VYDQKKTGII DHVDEVRWDI RPSPHLGTLE MRICDGVSNL
260 270 280 290 300
HELAALVALT HCLVVDLDRR LEADESLPTM PPWHHQENKW RAARYGLDAV
310 320 330 340 350
IILDADSNER LVTEDLDDVL NRLEPVARKL QCADELAAVA DIPRHGASYQ
360 370
RQRRVAEEHD GDLRAVVDAL VAELEI
Length:376
Mass (Da):42,552
Last modified:April 26, 2005 - v2
Checksum:iC7089754BB14E87F
GO

Sequence cautioni

The sequence AAS06472 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA Translation: AAS06472.1 Different initiation.
RefSeqiWP_015632730.1, NC_002944.2

Genome annotation databases

EnsemblBacteriaiAAS06472; AAS06472; MAP_3922
GeneIDi2719338
KEGGimpa:MAP_3922

Similar proteinsi

Entry informationi

Entry nameiGCS2_MYCPA
AccessioniPrimary (citable) accession number: Q73T00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health