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Q73SZ2 (PSD_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MAP_3930c
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000029777
Chain209 – 24032Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000029778

Sites

Site208 – 2092Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2091Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73SZ2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5FD84FBE65B4D043

FASTA24025,051
        10         20         30         40         50         60 
MARRPRTIGP SAADPGFSPQ HALELVRSAI PPVHPAGRPF VGAGLALALA GRRHRWLRRA 

        70         80         90        100        110        120 
GLLAAGACAG FFRHPPRVPP TRPGAIVAPA DGEICVIDVA TPPAELSMGD VALPRVSIFL 

       130        140        150        160        170        180 
SLLDAHVQRA PVSGEVIDVQ HRPGRFGSAD LAAASTENER TSLRIRTPGG AEVVAVQVAG 

       190        200        210        220        230        240 
LLARRIICDA HVGDKLSIGD TYGLIRFGSR LDTYLPAGAQ PLVTVGQRAI AGETVLAELP

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS06480.1.
RefSeqNP_962864.1. NC_002944.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000037811; EBMYCP00000036200; EBMYCG00000037806.
GeneID2721237.
GenomeReviewsGene locus MAP_3930c in contig AE016958_GR.
KEGGmpa:MAP3930c.
NMPDRfig|262316.1.peg.3930.
PATRIC18000752. VBIMycAvi108102_4182.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCPA
AccessionPrimary (citable) accession number: Q73SZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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