ID   Q73SX1_MYCPA            Unreviewed;       507 AA.
AC   Q73SX1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
GN   OrderedLocusNames=MAP_3952 {ECO:0000313|EMBL:AAS06502.1};
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS06502.1, ECO:0000313|Proteomes:UP000000580};
RN   [1] {ECO:0000313|EMBL:AAS06502.1, ECO:0000313|Proteomes:UP000000580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AE016958; AAS06502.1; -; Genomic_DNA.
DR   RefSeq; WP_003873756.1; NZ_CP106873.1.
DR   AlphaFoldDB; Q73SX1; -.
DR   STRING; 262316.MAP_3952; -.
DR   KEGG; mpa:MAP_3952; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_0_11; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07116; ALDH_ACDHII-AcoD; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR43111; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   PANTHER; PTHR43111:SF1; ALDEHYDE DEHYDROGENASE B-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT   DOMAIN          28..494
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        263
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   507 AA;  54770 MW;  ED50FBCE02B2F70F CRC64;
     MTVFARPGSA GALMSYESRY DNFIGGQWVA PARGRYFENP TPVTGQTFCE VARSDEADVD
     KALDAAHAAA PAWGKTAPAE RAAILNKIAD RIEENLESLA VAEVWDNGKP IREALAADIP
     LAADHFRYFA GALRAQEGSL SQIDDDTVAY HFHEPLGVVG QIIPWNFPIL MGAWKLAPAL
     AAGNAVVLKP AEQTPVSVLY LMSLIGDLLP PGVVNVVNGF GAEAGKPLAS SNRIAKIAFT
     GETTTGRLIM QYASQNLIPV TLELGGKSPN IFFSDVMAKA DDYQDKALEG FTMFALNQGE
     VCTCPSRSLI QADIYDEFLE LAAIRTKAVR QGDPLDSETM LGSQASNDQL EKVLSYIAIG
     KDEGATIITG GERAELGGDL SGGFYMQPTI FAGNNKMRIF QEEIFGPVVA VTSFTDYDDA
     ISIANDTLYG LGAGVWSRDG NTAYRAGRDI QAGRVWVNCY HAYPAHAAFG GYKQSGIGRE
     NHKMMLDHYQ QTKNMLVSYS NKAQSFF
//