Q73SV2 (DEOC_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	MAP_3971

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000231549
Sites
	Active site	158	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	188	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73SV2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BE84B9CB0BEA82E1	FASTA	223	21,799
	10 20 30 40 50 60 MTPTRAQLAA FVDHTLLKPE ATAADVAALV TEAAELGVYA VCVSPTMVPA AVQAGAGVRV 70 80 90 100 110 120 ASVAGFPSGK HVSAVKAHEA ALAVASGAAE IDMVIDVGAA LAGDLDGVRA DIAAVRDAVG 130 140 150 160 170 180 GAVLKVIVES SALLALADEH TLVRVCRAAE DAGADFVKTS TGFHPTGGAS VRAVALMAEA 190 200 210 220 VGGRLGVKAS GGIRTAADAL AMLDAGATRL GLSGTRAVLD GLG

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS06521.1.
RefSeq	NP_962905.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73SV2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038116; EBMYCP00000036505; EBMYCG00000038111.
GeneID	2719049.
GenomeReviews	Gene locus MAP_3971 in contig AE016958_GR.
KEGG	mpa:MAP3971.
NMPDR	fig|262316.1.peg.3971.
PATRIC	18000834. VBIMycAvi108102_4223.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017372.
HOGENOM	HBG636421.
OMA	IDHTNLK.
ProtClustDB	PRK00507.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_MYCPA

Accession

Primary (citable) accession number: Q73SV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program