Q73SU2 (GPMA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Synonyms:	gpm
Ordered Locus Names:	MAP_3981

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP MF_01039		PRO_0000179892
Sites
	Active site	12	1	Tele-phosphohistidine intermediate By similarity
	Active site	183	1	By similarity
	Site	63	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73SU2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2BD8C732CB982434	FASTA	249	27,231
	10 20 30 40 50 60 MGETATLVLL RHGESEWNSL NLFTGWVDVG LTDKGRAEAV RSGELLAEQG LLPDALYTSL 70 80 90 100 110 120 LRRAITTAHL ALDAADRLWI PVRRSWRLNE RHYGALQGLD KAETKARYGE EQFMAWRRSY 130 140 150 160 170 180 DTPPPPIERG STYSQDADPR YADIGGGPLT ECLADVVVRF LPYFTDVIVP DLRSGKTVLI 190 200 210 220 230 240 VAHGNSLRAL VKHLDQMSDD DVVGLNIPTG IPLRYDLDAR LRPLVPGGTY LDPEAAAAGA AAVASQGRG

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS06531.1.
RefSeq	NP_962915.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q73SU2.
SMR	Q73SU2. Positions 4-239.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000036593; EBMYCP00000034982; EBMYCG00000036588.
GeneID	2720038.
GenomeReviews	Gene locus MAP_3981 in contig AE016958_GR.
KEGG	mpa:MAP3981.
NMPDR	fig|262316.1.peg.3981.
PATRIC	18000856. VBIMycAvi108102_4234.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015087.
HOGENOM	HBG658938.
OMA	EWNALNL.
ProtClustDB	PRK14120.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_MYCPA

Accession

Primary (citable) accession number: Q73SU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program