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Q73S23

- GLMS_MYCPA

UniProt

Q73S23 - GLMS_MYCPA

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, MAP_4253
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei619 – 6191For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-4302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:MAP_4253
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 624623Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135355Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262316.MAP4253.

Structurei

3D structure databases

ProteinModelPortaliQ73S23.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 226225Glutamine amidotransferase type-2
Add
BLAST
Domaini297 – 436140SIS 1
Add
BLAST
Domaini469 – 614146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73S23-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYVGQ QPACAVVMAA LRRMEYRGYD SSGVALVNGD GTLTVSRRAG    50
RLANLEEAVA QLPPSALTGT TGLGHTRWAT HGRPTDRNAH PHRDAAGKIA 100
VVHNGIIENY AGLRHELEAD GVEFASDTDT EVAVHLVAQA YRHGPTAGDF 150
AASVLAVLRR LDGHFTLVFA NADEPGTIVA ARRSTPLVIG IGDGEMFVGS 200
DVAAFIPHTR NAIELGQDQA VVLTADGYRI TDFDGNDDLG PGAYREFHID 250
WDLAAAEKGG YEYFMLKEIA EQPAAVADTL LGHFVDGRIV LDEQRLSDQE 300
LREVDKVFVV ACGTAYHSGL LAKYAIEHWT RLPVEVELAS EFRYRDPVLD 350
RSTLVVAISQ SGETADTLEA VRHAKEQKAK VLAICNTNGS QIPRECDAVL 400
YTRAGPEIGV ASTKTFLAQI TANYLVGLAL AQARGTKYPD EVEREYHELE 450
AMPDLVARVL ATIKPVAALA QRFAQSPTVL FLGRHVGYPV ALEGALKLKE 500
LAYMHAEGFA AGELKHGPIA LIEDDLPVIV IMPSPKGSAV LHAKLLSNIR 550
EIQARGAITI VIAEEGDDTV RPYADHLIEI PSVSTLLQPL LSTIPLQVFA 600
ASVAQARGYD VDKPRNLAKS VTVE 624
Length:624
Mass (Da):67,199
Last modified:January 23, 2007 - v3
Checksum:iA881AAAE94EEC58F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS06803.1.
RefSeqiNP_963187.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS06803; AAS06803; MAP_4253.
GeneIDi2720189.
KEGGimpa:MAP4253.
PATRICi18001452. VBIMycAvi108102_4527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS06803.1 .
RefSeqi NP_963187.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73S23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP4253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS06803 ; AAS06803 ; MAP_4253 .
GeneIDi 2720189.
KEGGi mpa:MAP4253.
PATRICi 18001452. VBIMycAvi108102_4527.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci MAVI262316:GCQR-4302-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiGLMS_MYCPA
AccessioniPrimary (citable) accession number: Q73S23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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