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Q73S23

- GLMS_MYCPA

UniProt

Q73S23 - GLMS_MYCPA

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei619 – 6191For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-4302-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:MAP_4253
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 624623Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135355Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262316.MAP4253.

Structurei

3D structure databases

ProteinModelPortaliQ73S23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 226225Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini297 – 436140SIS 1UniRule annotationAdd
BLAST
Domaini469 – 614146SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q73S23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYVGQ QPACAVVMAA LRRMEYRGYD SSGVALVNGD GTLTVSRRAG
60 70 80 90 100
RLANLEEAVA QLPPSALTGT TGLGHTRWAT HGRPTDRNAH PHRDAAGKIA
110 120 130 140 150
VVHNGIIENY AGLRHELEAD GVEFASDTDT EVAVHLVAQA YRHGPTAGDF
160 170 180 190 200
AASVLAVLRR LDGHFTLVFA NADEPGTIVA ARRSTPLVIG IGDGEMFVGS
210 220 230 240 250
DVAAFIPHTR NAIELGQDQA VVLTADGYRI TDFDGNDDLG PGAYREFHID
260 270 280 290 300
WDLAAAEKGG YEYFMLKEIA EQPAAVADTL LGHFVDGRIV LDEQRLSDQE
310 320 330 340 350
LREVDKVFVV ACGTAYHSGL LAKYAIEHWT RLPVEVELAS EFRYRDPVLD
360 370 380 390 400
RSTLVVAISQ SGETADTLEA VRHAKEQKAK VLAICNTNGS QIPRECDAVL
410 420 430 440 450
YTRAGPEIGV ASTKTFLAQI TANYLVGLAL AQARGTKYPD EVEREYHELE
460 470 480 490 500
AMPDLVARVL ATIKPVAALA QRFAQSPTVL FLGRHVGYPV ALEGALKLKE
510 520 530 540 550
LAYMHAEGFA AGELKHGPIA LIEDDLPVIV IMPSPKGSAV LHAKLLSNIR
560 570 580 590 600
EIQARGAITI VIAEEGDDTV RPYADHLIEI PSVSTLLQPL LSTIPLQVFA
610 620
ASVAQARGYD VDKPRNLAKS VTVE
Length:624
Mass (Da):67,199
Last modified:January 23, 2007 - v3
Checksum:iA881AAAE94EEC58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS06803.1.
RefSeqiNP_963187.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS06803; AAS06803; MAP_4253.
GeneIDi2720189.
KEGGimpa:MAP4253.
PATRICi18001452. VBIMycAvi108102_4527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS06803.1 .
RefSeqi NP_963187.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q73S23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP4253.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS06803 ; AAS06803 ; MAP_4253 .
GeneIDi 2720189.
KEGGi mpa:MAP4253.
PATRICi 18001452. VBIMycAvi108102_4527.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci MAVI262316:GCQR-4302-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiGLMS_MYCPA
AccessioniPrimary (citable) accession number: Q73S23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3