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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-4306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:MAP_4257Imported
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)Imported
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP4257.

Structurei

3D structure databases

ProteinModelPortaliQ73S19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73S19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQHPSLPAH AIAPAYTGRL FTAPVPALRM PDESMDPDAA YRFIHDELML
60 70 80 90 100
DGSSRLNLAT FVTTWMDPEA GRLMAETFDK NMIDKDEYPA TAAIEQRCVC
110 120 130 140 150
MVADLFHAEG LNDADPYSAC GVSTIGSSEA VMLGGLAMKW RWRAKTKDWK
160 170 180 190 200
KRTPNLVMGS NVQVVWEKFC RYFDVEPRYL PMEEGRYVIT PEQVVDAVDE
210 220 230 240 250
DTIGVVAILG TTYTGELEPV ADICGALDKL ALKPASAGGV DVPVHVDAAS
260 270 280 290 300
GGFVVPFLHP ELKWDFRLPR VVSINVSGHK YGLTYPGVGF VVWRSKEYLP
310 320 330 340 350
DELVFRVNYL GGDMPTFTLN FSRPGNQVVG QYYNFLRLGR EGYTKVMQTL
360 370 380 390 400
SGTARWLGEQ LRVSEHCELI SDGSAIPVVA FRLAKNRGYT EFDVSHELRT
410 420 430 440 450
YGWQVPAYTM PDNATDVSVL RIVVREGLSA DLARALHDDA VSALTSLDKV
460
KPGGHYDAQH FAH
Length:463
Mass (Da):51,330
Last modified:July 5, 2004 - v1
Checksum:i56A451D8BEFD192D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS06807.1.
RefSeqiNP_963191.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS06807; AAS06807; MAP_4257.
GeneIDi2719594.
KEGGimpa:MAP4257.
PATRICi18001460. VBIMycAvi108102_4531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016958 Genomic DNA. Translation: AAS06807.1.
RefSeqiNP_963191.1. NC_002944.2.

3D structure databases

ProteinModelPortaliQ73S19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP4257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS06807; AAS06807; MAP_4257.
GeneIDi2719594.
KEGGimpa:MAP4257.
PATRICi18001460. VBIMycAvi108102_4531.

Phylogenomic databases

KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-4306-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10Imported.

Entry informationi

Entry nameiQ73S19_MYCPA
AccessioniPrimary (citable) accession number: Q73S19
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.