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Q73RR6 (FTHS_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TDE_0019
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199405

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73RR6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 408B1B43A2DA6308

FASTA55459,521
        10         20         30         40         50         60 
MKTDIEIARE AKLKKIAEIA DGLGIHDDNV IPYGKYIAKV PYSVIDDAKV KKNNLILVTA 

        70         80         90        100        110        120 
ITPTKAGIGK TTVSIGLALG LNKIGKKAVA ALREPSLGPC FGMKGGAAGG GYAQVLPMED 

       130        140        150        160        170        180 
INLHFTGDFH AITSAHNMIS ALFDNYIFRA QGTPKAIKTV LWKRVLDVND RNLRQVVTGL 

       190        200        210        220        230        240 
GEGNGVVMES GFDITPASEI MAIFCLAKDI EDLRRRIENI ILGYDTENNA VKVKDLGIAG 

       250        260        270        280        290        300 
SIVVLLKNAI NPNLVQTTEN TPAFIHGGPF ANIAHGCNSV IATKTALTYG EYVITEAGFA 

       310        320        330        340        350        360 
ADLGAEKFFD IKCRKAGLNP KLTIIAATTG GLKMHGDVPE KEISKPNAEA LKKGLANLDK 

       370        380        390        400        410        420 
HIENMKKFGQ TVVVALNRYG YDIDSELELV RKHCEAQGVG FAVNNAFVEG GKGAVELAEL 

       430        440        450        460        470        480 
VVKTIETNPS KPLKFVYEDK DSIKTKIGKI CKEIYGAADV TYSGAADKMI KKIEEAGMAD 

       490        500        510        520        530        540 
FPVCVAKTQY SFSSDPKLYG VPTGFEMNVR DIVLNSGSEM IVAIMGDMMR MPGLPKDPQA 

       550 
VRIDLVNGNV EGLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS10517.1.
RefSeqNP_970636.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73RR6.
SMRQ73RR6. Positions 4-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE0019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS10517; AAS10517; TDE_0019.
GeneID2741634.
KEGGtde:TDE0019.
PATRIC20522302. VBITreDen445_0021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-19-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_TREDE
AccessionPrimary (citable) accession number: Q73RR6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways