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Q73RR6

- FTHS_TREDE

UniProt

Q73RR6 - FTHS_TREDE

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-19-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TDE_0019
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_0000199405Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243275.TDE0019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73RR6.
    SMRiQ73RR6. Positions 4-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiDPKKINA.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73RR6-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIARE AKLKKIAEIA DGLGIHDDNV IPYGKYIAKV PYSVIDDAKV    50
    KKNNLILVTA ITPTKAGIGK TTVSIGLALG LNKIGKKAVA ALREPSLGPC 100
    FGMKGGAAGG GYAQVLPMED INLHFTGDFH AITSAHNMIS ALFDNYIFRA 150
    QGTPKAIKTV LWKRVLDVND RNLRQVVTGL GEGNGVVMES GFDITPASEI 200
    MAIFCLAKDI EDLRRRIENI ILGYDTENNA VKVKDLGIAG SIVVLLKNAI 250
    NPNLVQTTEN TPAFIHGGPF ANIAHGCNSV IATKTALTYG EYVITEAGFA 300
    ADLGAEKFFD IKCRKAGLNP KLTIIAATTG GLKMHGDVPE KEISKPNAEA 350
    LKKGLANLDK HIENMKKFGQ TVVVALNRYG YDIDSELELV RKHCEAQGVG 400
    FAVNNAFVEG GKGAVELAEL VVKTIETNPS KPLKFVYEDK DSIKTKIGKI 450
    CKEIYGAADV TYSGAADKMI KKIEEAGMAD FPVCVAKTQY SFSSDPKLYG 500
    VPTGFEMNVR DIVLNSGSEM IVAIMGDMMR MPGLPKDPQA VRIDLVNGNV 550
    EGLS 554
    Length:554
    Mass (Da):59,521
    Last modified:July 5, 2004 - v1
    Checksum:i408B1B43A2DA6308
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS10517.1.
    RefSeqiNP_970636.1. NC_002967.9.
    WP_010956670.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS10517; AAS10517; TDE_0019.
    GeneIDi2741634.
    KEGGitde:TDE0019.
    PATRICi20522302. VBITreDen445_0021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS10517.1 .
    RefSeqi NP_970636.1. NC_002967.9.
    WP_010956670.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali Q73RR6.
    SMRi Q73RR6. Positions 4-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE0019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS10517 ; AAS10517 ; TDE_0019 .
    GeneIDi 2741634.
    KEGGi tde:TDE0019.
    PATRICi 20522302. VBITreDen445_0021.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi DPKKINA.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TDEN243275:GJ7G-19-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiFTHS_TREDE
    AccessioniPrimary (citable) accession number: Q73RR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3