ID   Q73RD5_TREDE            Unreviewed;       692 AA.
AC   Q73RD5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS10652.1};
GN   OrderedLocusNames=TDE_0154 {ECO:0000313|EMBL:AAS10652.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS10652.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS10652.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS10652.1; -; Genomic_DNA.
DR   RefSeq; NP_970771.1; NC_002967.9.
DR   RefSeq; WP_002681032.1; NC_002967.9.
DR   AlphaFoldDB; Q73RD5; -.
DR   STRING; 243275.TDE_0154; -.
DR   PaxDb; 243275-TDE_0154; -.
DR   GeneID; 2741742; -.
DR   KEGG; tde:TDE_0154; -.
DR   PATRIC; fig|243275.7.peg.152; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_000445_105_5_12; -.
DR   OrthoDB; 338211at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        384..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          457..581
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   692 AA;  77961 MW;  9EE43C35B8E37989 CRC64;
     MTVEKKRLFL GSIPFCFLLI LLCLTNLFKP IYEQKVINLE VKNGKVSLPA KTLSGTALFS
     LSGDFHYTPN QFYSLRNSTE ESYAKVPGDF SSKDLENVFG YGSYGLELYG MDPETIYAIQ
     VPLIFSSCSI VINGMDLERQ GQPGIDRETE RPGTRSSQIA FRPLKDGTSN IVINVSNFFN
     NKGYISGPII LGESTQIGTM FKEDLIFSGM IFAVTFSVAL FFFMLSFFHK DSSFVIWFAL
     TCIVLALRGI FFYPYIFDIL FLNTPWLFNF IMRCVTVPLP IILFTIFITK ALKLRFKIPY
     IIILSVSILY AISTIVLPPE ISTFLLGYYQ VFALFCVSYI ISIAIIGLKK KKEFSVWIFT
     ATSVLFLFGV YDLFVSLGII SGDFFIQIGT VFAVIILSIM VLDDYSGSIT KIEDLSVEMK
     LINRSLIRFV PDQIVELLNK KSIADVQLGD SVELTMPIIS IDIRSFTHTS EKLAPNQVFE
     LLNEYFALVA PIVRKYNGVI TKYLGDGFFA LFPDGANAAL SCGIAIQKAI RDNSIAAPNS
     SPIKIGIGID MGDILLGIIG NSTRMDSIII SNAYHIAEVL QESTKKYSSC IIISDRIYDS
     LNDISEHYIR PIQKIKNTLN KDVFLYEVYD GDDDSIRDLK YSTQHYMENA LKVLSTKGVE
     AAGKYFDKIL EIFPNDYVAL YYKKMFEKIN LE
//