ID   Q73R86_TREDE            Unreviewed;       354 AA.
AC   Q73R86;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS10702.1};
GN   OrderedLocusNames=TDE_0205 {ECO:0000313|EMBL:AAS10702.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS10702.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS10702.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS10702.1; -; Genomic_DNA.
DR   RefSeq; NP_970821.1; NC_002967.9.
DR   RefSeq; WP_002681105.1; NC_002967.9.
DR   AlphaFoldDB; Q73R86; -.
DR   STRING; 243275.TDE_0205; -.
DR   PaxDb; 243275-TDE_0205; -.
DR   GeneID; 2739811; -.
DR   KEGG; tde:TDE_0205; -.
DR   PATRIC; fig|243275.7.peg.199; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_782891_0_0_12; -.
DR   OrthoDB; 9801841at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR045983; GUC-dom-containing_N.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF19363; DUF5939; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212}.
FT   DOMAIN          181..300
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   354 AA;  39772 MW;  C7F9692632EE498F CRC64;
     MNLNLQYNQN QEEADKIAAS LSALQEEKLF HIDVYGLAEE LSLNRETALN IFIQGVYDGF
     FIIDWIYHCP TCGSVAHETL SIHEAVSENY CPACQKNFNN TLDDNIEVFF SIHPNILPLD
     SSLKENYLAK IETDVNEGNY LTWKTPNSIK GIDLIQNNLY RDLMGSDVLI PGQSLQVMKA
     AILFTDIKGS TLMYSELGDA KAFALVRDHF IILFDVIKKF GGVPVKTIGD AIMGVFMNSK
     KAVDASIEAQ KELHEHYKNN PEIEKIEVKI GIHAGPALVV TLNNRLDYFG TSVNMAARIQ
     NAAQPNEVVI SEELFNNNEI QKSIAAITNK VQRQRITFKG IKEESTIYHI KVKD
//