ID   ALF1_TREDE              Reviewed;         295 AA.
AC   Q73QV3;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Fructose-bisphosphate aldolase class 1;
DE            EC=4.1.2.13;
DE   AltName: Full=Fructose-biphosphate aldolase class I;
DE            Short=FBP aldolase;
GN   Name=fda; OrderedLocusNames=TDE_0340;
OS   Treponema denticola.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=158;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / CIP 103919 / DSM 14222;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H.,
RA   Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F.,
RA   Durkin S.A., Daugherty S.C., Shetty J., Shvartsbeyn A.,
RA   Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B.,
RA   Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A.,
RA   Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola
RT   with other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate = glycerone
CC       phosphate + D-glyceraldehyde 3-phosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 4/4.
CC   -!- SIMILARITY: Belongs to the class I fructose-bisphosphate aldolase
CC       family.
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DR   EMBL; AE017226; AAS10835.1; -; Genomic_DNA.
DR   RefSeq; NP_970954.1; -.
DR   GeneID; 2739339; -.
DR   GenomeReviews; AE017226_GR; TDE_0340.
DR   KEGG; tde:TDE0340; -.
DR   NMPDR; fig|243275.1.peg.337; -.
DR   TIGR; TDE_0340; -.
DR   HOGENOM; Q73QV3; -.
DR   OMA; Q73QV3; GTKMRSV.
DR   BioCyc; TDEN243275:TDE_0340-MON; -.
DR   BRENDA; 4.1.2.13; 21150.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00729; -; 1.
DR   InterPro; IPR000741; Aldolase_I.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00274; Glycolytic; 1.
DR   ProDom; PD001128; Aldolase_I; 1.
DR   PROSITE; PS00158; ALDOLASE_CLASS_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Glycolysis; Lyase; Schiff base.
FT   CHAIN         1    295       Fructose-bisphosphate aldolase class 1.
FT                                /FTId=PRO_0000216914.
FT   ACT_SITE    176    176       Proton acceptor (By similarity).
FT   ACT_SITE    213    213       Schiff-base intermediate with
FT                                dihydroxyacetone-P (By similarity).
SQ   SEQUENCE   295 AA;  32805 MW;  5C1A6403A7D4EA20 CRC64;
     MDKVKLERMK NDKGFIAALD QSGGSTPKAL AAYGVPETAY SNEKEMFDLV HAMRTRIITG
     KAFNSNNILG AILFEQTMER EIEGMPTADF LWEKKKILPF LKVDKGLADL KDGVQLMKPI
     PNLDAMLKHA VEKHIFGTKM RSVIKEANPK GIKAVVDQQF ELGIQIAKAG LVPIIEPEVD
     IKSPDKAKCE EILKKELEEH LKTLPKDLLV MFKLSIPTKE NLYEEFTKHP QVVRVVALSG
     GYSRDDANKL LAKNRGMIAS FSRALAEGLF ASQSDAEFNA TLEKTIKGVY EASIT
//