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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton acceptorUniRule annotation
Active sitei213 – 2131Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-347-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:TDE_0340
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Fructose-bisphosphate aldolase class 1PRO_0000216914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE0340.

Structurei

3D structure databases

ProteinModelPortaliQ73QV3.
SMRiQ73QV3. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3588.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73QV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVKLERMK NDKGFIAALD QSGGSTPKAL AAYGVPETAY SNEKEMFDLV
60 70 80 90 100
HAMRTRIITG KAFNSNNILG AILFEQTMER EIEGMPTADF LWEKKKILPF
110 120 130 140 150
LKVDKGLADL KDGVQLMKPI PNLDAMLKHA VEKHIFGTKM RSVIKEANPK
160 170 180 190 200
GIKAVVDQQF ELGIQIAKAG LVPIIEPEVD IKSPDKAKCE EILKKELEEH
210 220 230 240 250
LKTLPKDLLV MFKLSIPTKE NLYEEFTKHP QVVRVVALSG GYSRDDANKL
260 270 280 290
LAKNRGMIAS FSRALAEGLF ASQSDAEFNA TLEKTIKGVY EASIT
Length:295
Mass (Da):32,805
Last modified:July 5, 2004 - v1
Checksum:i5C1A6403A7D4EA20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS10835.1.
RefSeqiNP_970954.1. NC_002967.9.
WP_002681313.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS10835; AAS10835; TDE_0340.
GeneIDi2739339.
KEGGitde:TDE0340.
PATRICi20522930. VBITreDen445_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS10835.1.
RefSeqiNP_970954.1. NC_002967.9.
WP_002681313.1. NC_002967.9.

3D structure databases

ProteinModelPortaliQ73QV3.
SMRiQ73QV3. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243275.TDE0340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS10835; AAS10835; TDE_0340.
GeneIDi2739339.
KEGGitde:TDE0340.
PATRICi20522930. VBITreDen445_0329.

Phylogenomic databases

eggNOGiCOG3588.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BioCyciTDEN243275:GJ7G-347-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiALF1_TREDE
AccessioniPrimary (citable) accession number: Q73QV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.