Reviewed, UniProtKB/Swiss-Prot Q73QV3 (ALF1_TREDE)

Names and origin

Protein names

Recommended name:
    Fructose-bisphosphate aldolase class 1
    EC=4.1.2.13
Alternative name(s):
    Fructose-biphosphate aldolase class I
      Short name=FBP aldolase

Gene names

Name:	fda
Ordered Locus Names:	TDE_0340

Organism

Treponema denticola [Complete proteome] [HAMAP]

Taxonomic identifier

158 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00729
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP MF_00729
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Fructose-bisphosphate aldolase class 1 HAMAP MF_00729		PRO_0000216914
Sites
	Active site	176	1	Proton acceptor By similarity
	Active site	213	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73QV3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5C1A6403A7D4EA20	FASTA	295	32,805
	10 20 30 40 50 60 MDKVKLERMK NDKGFIAALD QSGGSTPKAL AAYGVPETAY SNEKEMFDLV HAMRTRIITG 70 80 90 100 110 120 KAFNSNNILG AILFEQTMER EIEGMPTADF LWEKKKILPF LKVDKGLADL KDGVQLMKPI 130 140 150 160 170 180 PNLDAMLKHA VEKHIFGTKM RSVIKEANPK GIKAVVDQQF ELGIQIAKAG LVPIIEPEVD 190 200 210 220 230 240 IKSPDKAKCE EILKKELEEH LKTLPKDLLV MFKLSIPTKE NLYEEFTKHP QVVRVVALSG 250 260 270 280 290 GYSRDDANKL LAKNRGMIAS FSRALAEGLF ASQSDAEFNA TLEKTIKGVY EASIT

References

[1]

"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes." Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C., Shetty J. , Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004) [PubMed: 15064399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017226 Genomic DNA. Translation: AAS10835.1.
RefSeq	NP_970954.1.
3D structure databases
SMR	Q73QV3. Positions 1-294.
ModBase	Search...
Genome annotation databases
GeneID	2739339.
GenomeReviews	Gene locus TDE_0340 in contig AE017226_GR.
KEGG	tde:TDE0340.
NMPDR	fig|243275.1.peg.337.
TIGR	TDE_0340.
Phylogenomic databases
HOGENOM	HBG307137.
OMA	GTKMRSV.
Enzyme and pathway databases
BioCyc	TDEN243275:TDE_0340-MONOMER.
BRENDA	4.1.2.13. 21150.
Family and domain databases
HAMAP	MF_00729. FBP_aldolase_1. [Tree]
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_TREDE

Accession

Primary (citable) accession number: Q73QV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)