ID   Q73QP2_TREDE            Unreviewed;       797 AA.
AC   Q73QP2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS10896.1};
GN   OrderedLocusNames=TDE_0401 {ECO:0000313|EMBL:AAS10896.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS10896.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS10896.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS10896.1; -; Genomic_DNA.
DR   RefSeq; NP_971015.1; NC_002967.9.
DR   RefSeq; WP_002681429.1; NC_002967.9.
DR   AlphaFoldDB; Q73QP2; -.
DR   STRING; 243275.TDE_0401; -.
DR   PaxDb; 243275-TDE_0401; -.
DR   GeneID; 2739410; -.
DR   KEGG; tde:TDE_0401; -.
DR   PATRIC; fig|243275.7.peg.390; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_354090_0_0_12; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          545..673
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   COILED          163..197
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   797 AA;  91141 MW;  E89B4FA35C13CA9D CRC64;
     MMINDLDKFL NRIKKIYVHP DTVKIASLII LAGLMVLPFS MTKMDLFNTS QKAVNLYPMT
     VLFSNLIQSG LNFFYVSSLL LFLLPIAFII IFVSIFQTRI SSKIVYFSAL VPISLYLSAS
     ISGMNLFANT PRWFYSLSPL TYFAFFIALI FHAFLIAHGI ISIKRQNESY VEYKRLLKEE
     ESKEELLNKR IADKLKKQKE KSLKNNPEPI QEEAFSIDKL LKQYITRFKN RKKRSHIKIK
     ITIVIIFTIL VILSTFIYTD LRNYNMLLTQ NVNTTGKSQA EQVAAIYSFS DGLHAKINAF
     IEGIRKTNLS SPFPFQRVDI ITTSNKQPVF LEEIDESTEL PFFDVFSYTT AAGQVRLISD
     EEKNISPEEA ALYIKHFKNQ ATVSTPIYKE DNGTCLYIYP VTFTRKEGQR LVGFSVVTYL
     KEILDRPYFQ AKVFVFSISA VFFYASIIIV LFLADFIANP IIFLCGNIRK TANILRGMIS
     SNAAVEADRL IFEENIKTHD EIKTLSIELK NIISLIRGIL PYVSFHTIQN AEKNLSSKSA
     TRDLCFLFTD IRGFTSMCEN MQPREVINIL NRYLDIETKI IFENGGDVDK YVGDEIMAFF
     SGPKKEINAC KAAMEIRKAM RREQKAALKE GSALVSVGIG INSGPVVFGP VGSKTRKDFT
     SIGDTVNLAA RLEGANKEYG SKSIISEEVY KNLSKDFICR ELDFIAVKGK TEAVRIYEIL
     QPTEKLTTEK LYDIKKLFET GLSYYRKRKW KHAEKYFSEC AEKYNDAPSK VFLRRVTHYQ
     VSPPKPKWSG VFVMNVK
//