ID   Q73QN2_TREDE            Unreviewed;       694 AA.
AC   Q73QN2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS10906.1};
GN   OrderedLocusNames=TDE_0411 {ECO:0000313|EMBL:AAS10906.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS10906.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS10906.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS10906.1; -; Genomic_DNA.
DR   RefSeq; NP_971025.1; NC_002967.9.
DR   RefSeq; WP_002681441.1; NC_002967.9.
DR   AlphaFoldDB; Q73QN2; -.
DR   STRING; 243275.TDE_0411; -.
DR   PaxDb; 243275-TDE_0411; -.
DR   GeneID; 2740157; -.
DR   KEGG; tde:TDE_0411; -.
DR   PATRIC; fig|243275.7.peg.398; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_12; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        348..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        375..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          439..572
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   694 AA;  77345 MW;  CE3800905F68D1C0 CRC64;
     MKKIRRLFFI SIPVFFIVLF FIYLGVFKQA EYFFYDDRMN RTASYFSPSD EIVLVLVDQK
     SLNYAASERG WTWPWPREAY ADIIDFFSGG GAKSVAFDML FTEPSSYGVA DDKKFADASR
     ESGIVIQIVF FDKVQGNTKS WPDSAPKPEQ LSKNGLGPAK ELPGIFPIEE IASSARLIGN
     VNSLSDSDGT IRRARLFYSW KNYKIPTLGV ASYFVGGNED EALPEELNLR FTKSIDDYLP
     YSAGDILKAQ ADIRAGRESE LNPEDFEDMY VFFGLYAPGL FDICQTPVSA SYPGVGIHIT
     LLDNILSGNR IVNTGFLINA LIILICIILA GLPEIFSEKI KSRTASIIVN AVSFLVFVAL
     YLFIAYYLFR LGIAIPAASV LAGMALSFVA SLAVSYMVEG KQRRYLKNAF KQYLSPAVIE
     QLIADPSQLK LGGERKEISI FFSDLQGFTS ISESLTPEAL TELLNDYLSD MSKIILDSGG
     TIDKYEGDAI IAFWNAPARV EHHARSALEA AWACQKKLEE RRADFEKRAG GRPFKMRIGL
     NTGFAIVGNM GSVSRFDYTM LGDSVNLAAR LEGLNKQFGS YTMCAEAAKK QAEESGTVLK
     FRELARAAVV GKSEPVVVYE VMDEKTYNEK KALLDSFDRG LKEFYAGNFK EALNIFVQTE
     EADPPSKHYA EKCKTLISQK PEGEWLGIWK ADTK
//