Q73PV9 (Q73PV9_TREDE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutase PIRNR PIRNR001338
Short name=N5-CAIR mutase PIRNR PIRNR001338
EC=5.4.99.18 PIRNR PIRNR001338

Gene names

Ordered Locus Names:

TDE_0687

Organism

Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]

Taxonomic identifier

243275 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity. PIRNR PIRNR001338
Catalytic activity	5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. PIRNR PIRNR001338
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. PIRNR PIRNR001338
Sequence similarities	Belongs to the AIR carboxylase family. PIRNR PIRNR001338

Ontologies

Keywords
Biological process	Purine biosynthesis PIRNR PIRNR001338
Molecular function	Isomerase PIRNR PIRNR001338
Technical term	3D-structure PDB 3RGG PDB 3RG8 Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: EC phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: InterPro phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	1	1	Blocked amino end (Met) PDB 3RGG

Sequences

	Sequence		Length	Mass (Da)
	Q73PV9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F91B7B6D09DD8C87	FASTA	159	17,196
	10 20 30 40 50 60 MRPLVIILMG SSSDMGHAEK IASELKTFGI EYAIRIGSAH KTAEHVVSML KEYEALDRPK 70 80 90 100 110 120 LYITIAGRSN ALSGFVDGFV KGATIACPPP SDSFAGADIY SSLRMPSGIS PALVLEPKNA 130 140 150 ALLAARIFSL YDKEIADSVK SYMESNAQKI IEDDSKLKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes." Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C., Shetty J. , Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004) [PubMed: 15064399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35405 / CIP 103919 / DSM 14222.
[2]	"Treponema denticola PurE Is a Bacterial AIR Carboxylase." Tranchimand S., Starks C.M., Mathews I.I., Hockings S.C., Kappock T.J. Biochemistry 0:0-0(2011) [PubMed: 21548610] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS), BLOCKED AMINO END (MET) AT MET-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017226 Genomic DNA. Translation: AAS11180.1.

RefSeq

NP_971299.1. NC_002967.9.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3RG8	X-ray	1.74	A/B/C/D/E/F/G/H	1-159	[»]
3RGG	X-ray	1.82	A/B/C/D	1-159	[»]

ProteinModelPortal

Q73PV9.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2740246.

GenomeReviews

Gene locus TDE_0687 in contig AE017226_GR.

KEGG

tde:TDE0687.

NMPDR

fig|243275.1.peg.682.

PATRIC

20523614. VBITreDen445_0667.

TIGR

TDE_0687.

Phylogenomic databases

HOGENOM

HBG301965.

OMA

RMPSGVA.

ProtClustDB

CLSK541688.

Enzyme and pathway databases

BioCyc

TDEN243275:TDE_0687-MONOMER.

Family and domain databases

InterPro

IPR024694. N5-CAIR_mutase_PurE.
IPR000031. N5-CAIR_Mutase_PurE_dom.
IPR001636. SAICAR_synth.
[Graphical view]

Gene3D

G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.

KO

K01588.

PANTHER

PTHR11609. SAICAR_synt. 1 hit.

Pfam

PF00731. AIRC. 1 hit.
[Graphical view]

PIRSF

PIRSF001338. AIR_carboxylase. 1 hit.

SMART

SM01001. AIRC. 1 hit.
[Graphical view]

SUPFAM

SSF52255. AIR_carboxyl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q73PV9_TREDE

Accession

Primary (citable) accession number: Q73PV9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)