Q73P70 (OTCC_TREDE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	TDE_0929

Organism

Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]

Taxonomic identifier

243275 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113052
Regions
	Region	65 – 69	5	Carbamoyl phosphate binding By similarity
	Region	279 – 282	4	Ornithine binding By similarity
Sites
	Binding site	116	1	Carbamoyl phosphate By similarity
	Binding site	143	1	Carbamoyl phosphate By similarity
	Site	40	1	Important for structural integrity By similarity
	Site	156	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73P70 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F76D4503F3190DB8	FASTA	338	38,189
	10 20 30 40 50 60 MLKEIRGKSA KNLRGRSFLK LLDFTTDEIR YLLDLSKNFK DMKRAGIPHR YLEGKNIVLL 70 80 90 100 110 120 FEKTSTRTRC SFEVAGYDLG MGVTYLDPNS SQMGHKESIE DTARVLGRMY DGIEYRGFSQ 130 140 150 160 170 180 ELVETLAEYS GVPVWNGLTD LFHPTQMLAD LLTIEEKFGY LKGLKFTYMG DARNNVANSL 190 200 210 220 230 240 MIACVKMGMH FTACSPKHLF PTEDLVAEAK KIAAQTGGSV TLTENVSEGT KGAHVLYTDI 250 260 270 280 290 300 WVSMGEPDSV WEERIKLLKP YQVNKAAMDN ADKDAIFLHC LPSFHDLKTT KGQEINKKFG 310 320 330 LPEMEVTNEV FESHKSVVFD EAENRMHTIK AVMYATMC

References

[1]

"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes." Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C., Shetty J. , Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004) [PubMed: 15064399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017226 Genomic DNA. Translation: AAS11420.1.
RefSeq	NP_971539.1. NC_002967.9.
3D structure databases
ProteinModelPortal	Q73P70.
SMR	Q73P70. Positions 12-337.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2740394.
GenomeReviews	Gene locus TDE_0929 in contig AE017226_GR.
KEGG	tde:TDE0929.
NMPDR	fig|243275.1.peg.922.
PATRIC	20524076. VBITreDen445_0897.
TIGR	TDE_0929.
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VRICTPE.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	TDEN243275:TDE_0929-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_TREDE

Accession

Primary (citable) accession number: Q73P70

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program