ID   Q73P67_TREDE            Unreviewed;       936 AA.
AC   Q73P67;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:AAS11423.1};
GN   OrderedLocusNames=TDE_0932 {ECO:0000313|EMBL:AAS11423.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS11423.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS11423.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS11423.1; -; Genomic_DNA.
DR   RefSeq; NP_971542.1; NC_002967.9.
DR   RefSeq; WP_002682238.1; NC_002967.9.
DR   AlphaFoldDB; Q73P67; -.
DR   STRING; 243275.TDE_0932; -.
DR   PaxDb; 243275-TDE_0932; -.
DR   GeneID; 2740397; -.
DR   KEGG; tde:TDE_0932; -.
DR   PATRIC; fig|243275.7.peg.900; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_12; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        558..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        588..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        615..636
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          677..811
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          871..904
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   936 AA;  106385 MW;  1FD8C626A44D138F CRC64;
     MVEKEKNKSA FIVFLQKNLN FIIAIVVFLI FTAFSFIKFG RNIENQVYDA MLKLKPEIKE
     KSEILLLNVD DFSIEQIGSW PWSRDVLADV LIRLKESGGK AAVFDIEYLS AGRAGANNAY
     VEHELPKEYT AVRQEFGEYI KEFSDAVAGK NIPLSEVKTI GQDMSDYFKS RIDELSDSIK
     QNVFRDNDAY MGAAVGFFEN AFLTINAVNI NIGGETKELK DFAYNNFLFT NVEDKTGLFK
     KETLANRKAA NEEYGMAPTI MPILQYARGA GFPNVVIDED GVRRRISLLT EYEGRYIGQL
     VFTPILHILE PEKIIRSRRK LILKNAKDPS DLEKRKDLTI PLDEEGNLLI NWLKKRFADT
     ENPENGSFKS LSVYALTYAD IMEKNLISLL EAIKDLQIRT ADGYLSYHNA VTSLESEYAR
     LDQWKKELLN KDKQDFKEYF AARSSFFDNY SKFLSGDFDK EIHSLFAKIK EQNGSNQYDD
     IDAYVTELFK NAKEEYKNYS EHINYINGFC NNAFAIIGYS GVGTSDLGVN PFWKSYPNVG
     THANIYNTIM NEDFIRPLPK WVSIILAFVI AIFTAFMMKK IERGFIKVLL GIVLLSLTLS
     IGILLFVFGK IYLQLFLPVI TVVISFIVIL LLNFIFSEKE KGFLRKAFGV YLSDDVVNEI
     IADPDKLTLG GEQKRITALF TDIKSFSTLS EKITPEHLVS VLNVYLTQMS DLILQEKGTI
     DKYIGDAIVS FFGAPMDLPD HAYRACLAAI RMKQAEAELN KQLYDVGDIP MPIFTRIGIN
     TGEMVVGNMG TEKKMNYTIM GNDVNLAARL EGVNKKYGTW ILASESTWNE TNDAFLGRRL
     DRVRVVGINT PVQLYNVMAV KSEAYAEMVQ LVGIFENAID FYRQREYQKA LNLFNKCLEV
     SPDDEPSKMY VERMKMLLAD AETAATHSDI VNMTSK
//