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Q73P28 (SYR_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:TDE_0971
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242116

Regions

Motif132 – 14211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q73P28 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7DBABA318100A0D7

FASTA59066,634
        10         20         30         40         50         60 
MEDIKTTWQK IIADTLNGIA PETCDKILPE QINIETPPNP EMGDVAFPLF TFAKSFKSSP 

        70         80         90        100        110        120 
AKIASDVCAR LLENEDIKKY GMPKAIGPYL NVFLAKGDLA SNVLDKVLKE KENYGKTSSL 

       130        140        150        160        170        180 
SGKRIMIEFS SPNTNKPLHL GHLRNDALGE SISRILKFCG ADVFKVNIIN DRGVHICKSM 

       190        200        210        220        230        240 
IAYQKFGEGK TPESENIKSD RFVGDMYVAF HKYSQENPEK AEAEAKQMLL DWEAGENKEL 

       250        260        270        280        290        300 
IGLWKKMNGW AIEGIKETYK RTGISFDKLY FESETYLKGK DQILKGLEAG VFYKEEDGSV 

       310        320        330        340        350        360 
WVDLAPIKLD KKVLLRSDGT SLYMTQDIGT AISRHKDWPF NQMIYVVGNE QEYHFKVLFY 

       370        380        390        400        410        420 
VLKQLGFEWA DDLYHLSYGM VNLPEGKMKS REGTVVDADD LINSLQDEAL KKIEENGREK 

       430        440        450        460        470        480 
EVGDAAVAAE NIAVGALHYF LLQVSPKKDM LFNPKESLSF TGNTGPYLQY MGARISSILR 

       490        500        510        520        530        540 
KAETAEGKEK LKDGKLNASL LTNESEWELL KTLEDFPEQV ERSALRKDPS ALTAYLYELS 

       550        560        570        580        590 
KAFSRFYRDC PILSGEDADL SYTRMELARA TKIVLQNAMN LVLIPFMEVM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS11462.1.
RefSeqNP_971581.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73P28.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE0971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS11462; AAS11462; TDE_0971.
GeneID2740543.
KEGGtde:TDE0971.
PATRIC20524152. VBITreDen445_0935.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-984-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_TREDE
AccessionPrimary (citable) accession number: Q73P28
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries