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Q73NZ9 (Q73NZ9_TREDE) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP-Rule MF_01208
Short name=OPRT HAMAP-Rule MF_01208
Short name=OPRTase HAMAP-Rule MF_01208
EC=2.4.2.10 HAMAP-Rule MF_01208
Gene names
Name:pyrE HAMAP-Rule MF_01208
Ordered Locus Names:TDE_1001
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP] EMBL AAS11491.1
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema ›

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP-Rule MF_01208 SAAS SAAS023031

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01208 SAAS SAAS023031

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP-Rule MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region138 – 14695-phosphoribose 1-diphosphate binding By similarity HAMAP-Rule MF_01208

Sites

Binding site10815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP-Rule MF_01208
Binding site11215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP-Rule MF_01208
Binding site11415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP-Rule MF_01208
Binding site1421Orotate By similarity HAMAP-Rule MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q73NZ9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8894316B77198E0B

FASTA23425,762
        10         20         30         40         50         60 
MHKDEKKIAE VQKKYGALLA KTAFELGALK LSPNEPFTWA SGYRMPIYND NRRFLALPEM 

        70         80         90        100        110        120 
RRTIAEAFAE LLKAVDFDPE WLAGTATAGI PHSVSLGDLL QKSVSYVRSG GKDHGLKNQI 

       130        140        150        160        170        180 
EGLGANADYK GADVLVVEDL ISTGGSSIKA VEAVRNANGK VPFCFAIFSY GFAEAEKAFA 

       190        200        210        220        230 
ELKPSCIPVT ILNYDIMLDE AVKQNYISEE NKKSLGEWRL DPFGWGEKHG FPKV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017226 Genomic DNA. Translation: AAS11491.1.
RefSeqNP_971610.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73NZ9.
ModBaseSearch...

Protein-protein interaction databases

STRING243275.TDE1001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS11491; AAS11491; TDE_1001.
GeneID2739078.
KEGGtde:TDE1001.
PATRIC20524206. VBITreDen445_0961.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00762.
OMARNARIEG.
ProtClustDBCLSK2761608.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1015-MONOMER.
UniPathwayUPA00070; UER00119.

Family and domain databases

HAMAPMF_01208. PyrE.
InterProIPR023031. OPRT.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ73NZ9_TREDE
AccessionPrimary (citable) accession number: Q73NZ9
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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