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Q73NM2 (TRMB_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase

EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:TDE_1130
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_01057

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_01057
PRO_0000171415

Regions

Region214 – 2174Substrate binding By similarity

Sites

Active site1431 By similarity
Binding site681S-adenosyl-L-methionine By similarity
Binding site931S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine By similarity
Binding site1431S-adenosyl-L-methionine By similarity
Binding site1471Substrate By similarity
Binding site1791Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73NM2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3CDCE9EC15A3EBA7

FASTA23527,516
        10         20         30         40         50         60 
MNSTEITQNT DVPSHFRSIK TFVLRTGRMT EGQKRNYEAF YQKWCIPYTE SPIDFQTLFQ 

        70         80         90        100        110        120 
NDNPVIIEIG FGMGTATAQI AEDNPDKNYL GIEVFKAGVG KLLGEIEEKK LNNLRIIEHD 

       130        140        150        160        170        180 
AIEVLENMIN NESVDGFHIF FPDPWQKKRN HKRRLVRRPR TDLLSKKLKD GGYIYMVTDW 

       190        200        210        220        230 
ENYAEDAFEQ LSETPNLKSK YEKFAPSQSW RPTTKFEKKG LKKEHVINEL IFEKD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS11619.1.
RefSeqNP_971738.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73NM2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE1130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS11619; AAS11619; TDE_1130.
GeneID2739989.
KEGGtde:TDE1130.
PATRIC20524468. VBITreDen445_1091.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0220.
KOK03439.
OMAERKGARE.
OrthoDBEOG6K6VBC.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1145-MONOMER.
UniPathwayUPA00989.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
HAMAPMF_01057. tRNA_methyltr_TrmB.
InterProIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
TIGRFAMsTIGR00091. TIGR00091. 1 hit.
PROSITEPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_TREDE
AccessionPrimary (citable) accession number: Q73NM2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways