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Q73NM2

- TRMB_TREDE

UniProt

Q73NM2 - TRMB_TREDE

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
    Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
    Active sitei143 – 1431By similarity
    Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
    Binding sitei147 – 1471SubstrateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-1145-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:TDE_1130
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235tRNA (guanine-N(7)-)-methyltransferasePRO_0000171415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243275.TDE1130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73NM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 2174Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiERKGARE.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73NM2-1 [UniParc]FASTAAdd to Basket

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    MNSTEITQNT DVPSHFRSIK TFVLRTGRMT EGQKRNYEAF YQKWCIPYTE    50
    SPIDFQTLFQ NDNPVIIEIG FGMGTATAQI AEDNPDKNYL GIEVFKAGVG 100
    KLLGEIEEKK LNNLRIIEHD AIEVLENMIN NESVDGFHIF FPDPWQKKRN 150
    HKRRLVRRPR TDLLSKKLKD GGYIYMVTDW ENYAEDAFEQ LSETPNLKSK 200
    YEKFAPSQSW RPTTKFEKKG LKKEHVINEL IFEKD 235
    Length:235
    Mass (Da):27,516
    Last modified:July 5, 2004 - v1
    Checksum:i3CDCE9EC15A3EBA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11619.1.
    RefSeqiNP_971738.1. NC_002967.9.
    WP_010956879.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS11619; AAS11619; TDE_1130.
    GeneIDi2739989.
    KEGGitde:TDE1130.
    PATRICi20524468. VBITreDen445_1091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11619.1 .
    RefSeqi NP_971738.1. NC_002967.9.
    WP_010956879.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali Q73NM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE1130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS11619 ; AAS11619 ; TDE_1130 .
    GeneIDi 2739989.
    KEGGi tde:TDE1130.
    PATRICi 20524468. VBITreDen445_1091.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi ERKGARE.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci TDEN243275:GJ7G-1145-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiTRMB_TREDE
    AccessioniPrimary (citable) accession number: Q73NM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3