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Q73MB8

- NADK_TREDE

UniProt

Q73MB8 - NADK_TREDE

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Protein

NAD kinase

Gene

nadK

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton acceptorUniRule annotation
Binding sitei145 – 1451NADUniRule annotation
Binding sitei162 – 1621NADUniRule annotation
Binding sitei164 – 1641NADUniRule annotation
Binding sitei235 – 2351NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 612NADUniRule annotation
Nucleotide bindingi134 – 1352NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:TDE_1591
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinasePRO_0000229709Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE1591.

Structurei

3D structure databases

ProteinModelPortaliQ73MB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiSAYRADG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73MB8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVLIVLSI EKPNAKKICK EIEAFLSAKG IDSFVYKYDG ISHSPELNED
60 70 80 90 100
YDLAISLGGD GTVLFTARYS APRHIPVFPI NLGRFGFIAN IEPKEWEGEL
110 120 130 140 150
LHLLNGKQAL HKRMLLSASI NRKNKEIVKY EALNDAVVSG SGIAKLINLD
160 170 180 190 200
ISFNGISFGV FRADGVIVST PTGSTAYSAA SGGPILDPDV SAFVLTPISP
210 220 230 240 250
FSLSNRPLVL PSSGQMKIKI LPARAKDIIV SIDGQEMVSL QEDDEIIISE
260 270 280
SPNKVKMAGC SPDNFYKALR SKLGWSGSSS PKLN
Length:284
Mass (Da):30,737
Last modified:July 5, 2004 - v1
Checksum:iCBB8D218AA802ADC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS12108.1.
RefSeqiNP_972197.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS12108; AAS12108; TDE_1591.
GeneIDi2739788.
KEGGitde:TDE1591.
PATRICi20525346. VBITreDen445_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS12108.1 .
RefSeqi NP_972197.1. NC_002967.9.

3D structure databases

ProteinModelPortali Q73MB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243275.TDE1591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS12108 ; AAS12108 ; TDE_1591 .
GeneIDi 2739788.
KEGGi tde:TDE1591.
PATRICi 20525346. VBITreDen445_1521.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi SAYRADG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci TDEN243275:GJ7G-1617-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiNADK_TREDE
AccessioniPrimary (citable) accession number: Q73MB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3