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Protein

NAD kinase

Gene

nadK

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Proton acceptorUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei162NADUniRule annotation1
Binding sitei164NADUniRule annotation1
Binding sitei235NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 61NADUniRule annotation2
Nucleotide bindingi134 – 135NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:TDE_1591
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297091 – 284NAD kinaseAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE1591.

Structurei

3D structure databases

ProteinModelPortaliQ73MB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q73MB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLIVLSI EKPNAKKICK EIEAFLSAKG IDSFVYKYDG ISHSPELNED
60 70 80 90 100
YDLAISLGGD GTVLFTARYS APRHIPVFPI NLGRFGFIAN IEPKEWEGEL
110 120 130 140 150
LHLLNGKQAL HKRMLLSASI NRKNKEIVKY EALNDAVVSG SGIAKLINLD
160 170 180 190 200
ISFNGISFGV FRADGVIVST PTGSTAYSAA SGGPILDPDV SAFVLTPISP
210 220 230 240 250
FSLSNRPLVL PSSGQMKIKI LPARAKDIIV SIDGQEMVSL QEDDEIIISE
260 270 280
SPNKVKMAGC SPDNFYKALR SKLGWSGSSS PKLN
Length:284
Mass (Da):30,737
Last modified:July 5, 2004 - v1
Checksum:iCBB8D218AA802ADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12108.1.
RefSeqiNP_972197.1. NC_002967.9.
WP_002679270.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS12108; AAS12108; TDE_1591.
GeneIDi2739788.
KEGGitde:TDE1591.
PATRICi20525346. VBITreDen445_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12108.1.
RefSeqiNP_972197.1. NC_002967.9.
WP_002679270.1. NC_002967.9.

3D structure databases

ProteinModelPortaliQ73MB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243275.TDE1591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS12108; AAS12108; TDE_1591.
GeneIDi2739788.
KEGGitde:TDE1591.
PATRICi20525346. VBITreDen445_1521.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_TREDE
AccessioniPrimary (citable) accession number: Q73MB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.