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Protein

NAD kinase

Gene

nadK

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Proton acceptorUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei162NADUniRule annotation1
Binding sitei164NADUniRule annotation1
Binding sitei235NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 61NADUniRule annotation2
Nucleotide bindingi134 – 135NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:G1G0Q-1617-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:TDE_1591
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297091 – 284NAD kinaseAdd BLAST284

Proteomic databases

PRIDEiQ73MB8

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE1591

Structurei

3D structure databases

ProteinModelPortaliQ73MB8
SMRiQ73MB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q73MB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLIVLSI EKPNAKKICK EIEAFLSAKG IDSFVYKYDG ISHSPELNED
60 70 80 90 100
YDLAISLGGD GTVLFTARYS APRHIPVFPI NLGRFGFIAN IEPKEWEGEL
110 120 130 140 150
LHLLNGKQAL HKRMLLSASI NRKNKEIVKY EALNDAVVSG SGIAKLINLD
160 170 180 190 200
ISFNGISFGV FRADGVIVST PTGSTAYSAA SGGPILDPDV SAFVLTPISP
210 220 230 240 250
FSLSNRPLVL PSSGQMKIKI LPARAKDIIV SIDGQEMVSL QEDDEIIISE
260 270 280
SPNKVKMAGC SPDNFYKALR SKLGWSGSSS PKLN
Length:284
Mass (Da):30,737
Last modified:July 5, 2004 - v1
Checksum:iCBB8D218AA802ADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA Translation: AAS12108.1
RefSeqiNP_972197.1, NC_002967.9
WP_002679270.1, NC_002967.9

Genome annotation databases

EnsemblBacteriaiAAS12108; AAS12108; TDE_1591
GeneIDi2739788
KEGGitde:TDE1591
PATRICifig|243275.7.peg.1521

Similar proteinsi

Entry informationi

Entry nameiNADK_TREDE
AccessioniPrimary (citable) accession number: Q73MB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health