Reviewed, UniProtKB/Swiss-Prot Q73M38 (CLPP1_TREDE)

Names and origin

Protein names

Recommended name:
    ATP-dependent Clp protease proteolytic subunit 1
    EC=3.4.21.92
Alternative name(s):
    Endopeptidase Clp 1

Gene names

Name:	clpP1
Ordered Locus Names:	TDE_1672

Organism

Treponema denticola [Complete proteome] [HAMAP]

Taxonomic identifier

158 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444		PRO_0000179702
Sites
	Active site	99	1	By similarity
	Active site	124	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q73M38-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 88A2675C0D4CC417	FASTA	197	21,751
	10 20 30 40 50 60 MSTLVPYVIE QTGNGERSYD IFSRLLKDRI IFVDGEINDM SADLVVAQLL FLEAQNPDKD 70 80 90 100 110 120 ISLYINSPGG SVTAGLAIYD TMQHIRPDVQ TICLGQCASM GAVLLAGGAK NKRYALPSSR 130 140 150 160 170 180 VMIHQPWGGV QGQAVDINIQ AKEIVRLKKL TIKYFAENTG KTEKQVAADM ERDFFMSAEE 190 ALTYGIIDTV MNRRKDG

References

[1]

"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes." Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F., Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C., Shetty J. , Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T. Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004) [PubMed: 15064399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017226 Genomic DNA. Translation: AAS12188.1.
RefSeq	NP_972277.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S14.001.
Genome annotation databases
GeneID	2740127.
GenomeReviews	Gene locus TDE_1672 in contig AE017226_GR.
KEGG	tde:TDE1672.
NMPDR	fig|243275.1.peg.1660.
TIGR	TDE_1672.
Phylogenomic databases
HOGENOM	Q73M38.
OMA	RKDIERD.
Enzyme and pathway databases
BioCyc	TDEN243275:TDE_1672-MON.
BRENDA	3.4.21.92. 21150.
Family and domain databases
HAMAP	MF_00444. [Tree]
InterPro	IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. clpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP1_TREDE

Accession

Primary (citable) accession number: Q73M38

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)