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Q73LJ8 (RUVC_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:TDE_1864
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000225186

Sites

Metal binding211Magnesium By similarity
Metal binding811Magnesium By similarity
Metal binding1541Magnesium By similarity
Metal binding1571Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73LJ8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EE9C83F73701E2C8

FASTA17819,095
        10         20         30         40         50         60 
MGILKAASSK KNLRPCVIGI DPGLANTGYG IISFSNNRFE CIEYGSISTE PHLLQGERLL 

        70         80         90        100        110        120 
KIFDKVSELI EKYRPKEAGI ETLYFAKNAT SAMSVSEARG VVLLALAQGG VRVGEYAPNS 

       130        140        150        160        170 
IKKAVTGIAQ AEKRQVQEAV KLILGLKEIP RPDHAADALA AAITKINLGD VGEVRAYV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS12379.1.
RefSeqNP_972468.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73LJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE1864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS12379; AAS12379; TDE_1864.
GeneID2740053.
KEGGtde:TDE1864.
PATRIC20525856. VBITreDen445_1769.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
KOK01159.
OMAYHPDEMA.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1897-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_TREDE
AccessionPrimary (citable) accession number: Q73LJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families