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Q73LF4 (DXS_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:TDE_1910
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6536531-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256501

Sequences

Sequence LengthMass (Da)Tools
Q73LF4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 37D8480E37B0F973

FASTA65371,550
        10         20         30         40         50         60 
MTKNSLLSKI KGPEDIKLLS YNELKDLAVE IRKEILTVVG HNGGHLASNL GVIELTLAIH 

        70         80         90        100        110        120 
RVFSSPHDAV VWDVGHQSYT HKMITGRQSR FSTLRLWEGL SGFPKREESV HDAFNTGHAS 

       130        140        150        160        170        180 
TSISAALGIL EGKRLNKDSG KVIAVIGDGA MTGGMAFEAL SNAGELKKDL IVIINDNKMS 

       190        200        210        220        230        240 
ISKNTGAFSE YLSRLTVHEG YQRFKYLFDK AVGSIPLVGN KLNSIIWRLK RGMKGIFYKN 

       250        260        270        280        290        300 
NIFVDFGFEY VGPINGHNMR ELEKVLKNVK KLNSPVVMLV ETIKGKGYPL AEINPAAFHG 

       310        320        330        340        350        360 
IGPFNIADGK VEKNDAITFT QAFGKALVKA AEKNSKIAAI TAAMESGTGL SLFHSKFPER 

       370        380        390        400        410        420 
FFDAGIAEGH AVTFAAGLAS AGMKPVTAIY STFLQRSIDQ IIHDTSIQNL PVIFAIDRAG 

       430        440        450        460        470        480 
PVPADGETHQ GLFDIALLRP VPNMTILCPA SEKELELMLS WALMQDNPIA IRYPKADCPK 

       490        500        510        520        530        540 
EIPEFSQSIE KGRGVLIKNS DKSRILITCT GGMYNEVKEA SAILAHRGLS TDIYNVRFAK 

       550        560        570        580        590        600 
PIDENYFLNI TKDYSYILFV EDGMKIGSLS SYLESLILRY ESNKTGSQSN KTGLQNKKTA 

       610        620        630        640        650 
VLAFEDMFFP HGTRSEIFKG AGVSAEHIVQ AAELLFTETH TVSASTAIPV KEN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017226 Genomic DNA. Translation: AAS12424.1.
RefSeqNP_972513.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73LF4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2740408.
GenomeReviewsGene locus TDE_1910 in contig AE017226_GR.
KEGGtde:TDE1910.
NMPDRfig|243275.1.peg.1896.
PATRIC20525934. VBITreDen445_1808.
TIGRTDE_1910.

Phylogenomic databases

HOGENOMHBG571647.
OMARAHEFES.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycTDEN243275:TDE_1910-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_TREDE
AccessionPrimary (citable) accession number: Q73LF4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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