ID   Q73L79_TREDE            Unreviewed;       636 AA.
AC   Q73L79;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   SubName: Full=Adenylate cyclase, putative {ECO:0000313|EMBL:AAS12500.1};
GN   OrderedLocusNames=TDE_1986 {ECO:0000313|EMBL:AAS12500.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS12500.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS12500.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; AE017226; AAS12500.1; -; Genomic_DNA.
DR   RefSeq; NP_972589.1; NC_002967.9.
DR   RefSeq; WP_002679721.1; NC_002967.9.
DR   AlphaFoldDB; Q73L79; -.
DR   STRING; 243275.TDE_1986; -.
DR   PaxDb; 243275-TDE_1986; -.
DR   GeneID; 2740439; -.
DR   KEGG; tde:TDE_1986; -.
DR   PATRIC; fig|243275.7.peg.1875; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3850; Bacteria.
DR   HOGENOM; CLU_016487_0_0_12; -.
DR   OrthoDB; 9806704at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          317..369
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          401..536
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          614..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..636
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  70089 MW;  BE75F9E78DEF69EB CRC64;
     MLKNEGVNEK VKFSIGAKLI TIISILVVFS LGTITGLVTW FVGEDIQTMS EESNRTVNFQ
     AGAAAEKELL SIKANAFLFL DVLNSTETGS GIAKQTADFY FERNPQVAAV LVTDARMNKR
     IYRKLVSTNF FLSRELDYSA IDEFIENEMD TAIQAEKGIE QVINASPFFG EPILVLFYPY
     REKGLDQGLV IFFSAETLSE NIGTGKLQTT YLVNNLGDIL IHPDFELTKN GINISDSKLF
     IEMREKGDMN RQILFTDKEG KKQFGAYRKI SIADLAVLTT AEADKVLEPV VRSTFKNVTL
     GIAVLALAVL FIWFFSKSIS SPVKALASAA GEIEQGNYEL DLKAKTKDEI GLLTNSFVRM
     GKGLAERERL KDSFGRFINK EIAELAMKGE LALGGETKET TIFFSDIRSF TAISEKLEPN
     EVVEFLNEYM TQMVECVNDT HGVVDKFIGD AVMAVWGAPT SAGNPREDAL NCIRAALRMR
     AALIIFNQGR GGDKKPIIRI GCGINSGPVV AGQIGSKKRM EYTVIGDAVN LASRTEALNK
     PLGTDILITE NTYRLVKDKV LVEEMPSVTV KGKSAPLRMF AVINMPEETD IPGAGEKGPK
     TLAQIRAKLG IPTPNLNKVD VNEDEKKYNI QAQNKQ
//