ID   Q73KV2_TREDE            Unreviewed;      1526 AA.
AC   Q73KV2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=HAMP domain protein {ECO:0000313|EMBL:AAS12635.1};
GN   OrderedLocusNames=TDE_2115 {ECO:0000313|EMBL:AAS12635.1};
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS12635.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS12635.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G., Malek J.,
RA   Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K., Pal S.,
RA   Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E., Baca E.,
RA   Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
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DR   EMBL; AE017226; AAS12635.1; -; Genomic_DNA.
DR   RefSeq; NP_972716.1; NC_002967.9.
DR   RefSeq; WP_010957154.1; NC_002967.9.
DR   STRING; 243275.TDE_2115; -.
DR   PaxDb; 243275-TDE_2115; -.
DR   GeneID; 2739374; -.
DR   KEGG; tde:TDE_2115; -.
DR   PATRIC; fig|243275.7.peg.1998; -.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_243603_0_0_12; -.
DR   OrthoDB; 9763484at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        750..773
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        816..837
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1097..1154
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   1526 AA;  170674 MW;  E1A7C26D3DFE4EB1 CRC64;
     MKKILTIFLM FLFFISFLSA KEFYWENPSV ISGRNGYFLK SASNANISAS VWEEVVKSSD
     TEGLIYISTG VYVNNKWTIN ERIIPPIPYT ADIPSIVSIA VGNDDSILIA LVKNRNTITI
     LKSTDYGKTY TVKNIVTEIY DLLSPQLSVA SNGKYLMFVS HGADEKFSIF YSSSEDGLNW
     PAFSEFNFAK KMDRIFLPAH TASSKNDVLV FQALDKSGDR RTYQLFSSFS SDGCSSWSEP
     VRITDNFDFN NQRPNLLYIN SEKSIFIVWE QSSYRSEKNS PAYAVLDSKG KLASSIEILP
     SGNGTMFSPR IIAYNNKPLI TWSETYDGKS SILIARKEDS IWKTDSVASI TGSLLFVNPF
     FVDGNLHIVW QEGVRAAKIM HIEPDHEVAK AQLQPLNFDS KTLEGRQKIT MKIKFPNDSS
     GIAGYSYEWS KDVPPEFVAP VIKKLKDETV LVYEPEEDGL WYLGVRVCDY AGNWSEMTTI
     SYERDIVPPA APIFDLLALD KKGFVKSNTF DIKWNPPDLD INGKPETAIN GYIWNLSYLG
     TVDKFLSYLK TAGSAFIDDD VVQKVLSDNL DVELNTSKIS SVSNKREFKN YENGLYALTV
     SAVDAFGNIG APAVKYFALN KYIPYTYVAD INAVQALDGS ISLSLVGKGF AAGGEVTSIY
     VDADGLPPYD LTIEKKDFSV LSDKLISNIK INYLDPGKYY VGLMHSGRGV YFAQKTISFD
     DIGNIKLGDY GKVYKYNWLL SAMDSDFSDY FLIICFTIFI LLIMTLSITG VIYSVKEAIK
     IKYEVTVLLR GGAMSFGKEK KLSALKVRGG GLRLKFMMFT MTLIISVILT LDLPLGFRFS
     ETQERLLAEG LASNTQVLLE SLSSGAKAYL PSKNVLELGF LPSQVSALKE ASFATITGVH
     IDNKKVGYNF VWASNDEDIL SKIDTPDFVV GKSELLLPQL ENVYKKLDEI DKEARDSVGE
     ISDEIQSLTD MTMLIALNTD LKSVERRNEI QSAINQMETK LSSELNGLSI KGSGSYPEFN
     SKKLSRDITS YLFYKPILYR QTGGQSNFVQ GMVYIQVSTQ SLIEQIDEAT TALRKVILLI
     SLGALSAGLV GAYILSSIIT APIKKLVRHV AMIAATEDKE LLAGKDVKLR TKDEIGVLGT
     TINEMTNGLV EAAAASKDLT MGKEIQKMFL PLDLDEAGRK LTSGKTVDDN VEFFGYYEGA
     RGVSGDYFDY IKLDDRYYAI IKCDVAGKGV PAALIMVEVA TLFLDYFRDW SYKKQGLKID
     QVVSRINDLL ESRGFKGRFA AFTLCIMDSI SGNVHFCNAG DNVINIYDAA LKKMKEVILT
     EVSAAGVFPT FMIDMKGGFK VETVKLNSGD VLFLYTDGIE EAKRLFRNSK LEPILCEEPG
     LEKDAEHETH SVGQDGEELG KPRVCKIIES IFARSSFSLK KWHNPIENEQ FDFDFTNLEG
     TIEDAVIGLV SVEKIFRMYQ DPKATERDMV QVDKKIDLFL NKHFRQYQTY CGNRVPNTSY
     NEYLYYTNVR EDQQYDDLTI LGIKKK
//