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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei632 – 6321ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-2381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TDE_2339
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligasePRO_0000152108Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE2339.

Structurei

3D structure databases

ProteinModelPortaliQ73K81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5412"HIGH" regionAdd
BLAST
Motifi629 – 6335"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q73K81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYPFSTIEP KWQKYWEENK TFKTVEDKNY PKDKRLYILD MFPYPSGDGL
60 70 80 90 100
HVGHPEGYTA TDIYSRFLRM SGYNVLHPMG FDSFGLPAEN YAIKTGIHPL
110 120 130 140 150
ITTRKNMETF RKQIKSIGLS YDWDREISTS EESYYKWTQW IFLQLFKKGL
160 170 180 190 200
AYEKEAPINW CPSCLTGLAN EEVKDGKCER CGAQIQRKNL RQWILKITEY
210 220 230 240 250
AERLLEDLDE LDWPESIKIM QKNWIGKSTG AEVDFALVDK DGKETGQKIK
260 270 280 290 300
VYTTRPDTIF GATYMVLAPE HELVKSITTS NQEKAVAAYI EEAAKKSDLE
310 320 330 340 350
RTDLAKNKTG VFTGAYAINP LTEQKIPVWI SDYILISYGT GAIMAVPAHD
360 370 380 390 400
ERDFEFAAQF NLPKIKVVAG AEEWESGKRD FSEEPKACTT EDGYSVNSKQ
410 420 430 440 450
FDGLKTEEAK TKITEHLENL GIAKRAVNYK LRDWIFSRQR YWGEPIPLVH
460 470 480 490 500
CPSCGIVPLN EHDLPLTLPQ VESYAPTGTG ESPLAAIDSW VNTKCPKCGK
510 520 530 540 550
EAKRETNTMP QWAGSCWYYL RFIDPHNNEA FADKEKCDYW MPVDLYVGGT
560 570 580 590 600
EHAVLHLLYA RFWHKVLYDL GLVSTKEPFT RLINQGMITS FAYMRKNKSL
610 620 630 640 650
VPVDKVKKIS ETEFEDIETG EKLEQVIAKM SKSLKNVINP DDIIKEYGAD
660 670 680 690 700
TLRLYEMFLG PLEVSKPWNT SGIMGVFRFL EKIWNLSDRE IYKTPVNDTS
710 720 730 740 750
TPETKTLTVL LNKTIKKVTE DTASLNFNTA ISQMMIFINE VSKHKKIPHY
760 770 780 790 800
VWYNFVKLLN PYAPHLAEEL WQKMGNDESI AYSHWPMFVE KFCVDQTCTV
810 820 830 840 850
VVQVNGKLRG KFEAEAGTSK EELERLALSN EGAIRNIEGK EIKKIITVPD

KLVNIVVQ
Length:858
Mass (Da):98,404
Last modified:July 5, 2004 - v1
Checksum:i087F7974B04C5837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12857.1.
RefSeqiNP_972938.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS12857; AAS12857; TDE_2339.
GeneIDi2739434.
KEGGitde:TDE2339.
PATRICi20526750. VBITreDen445_2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12857.1.
RefSeqiNP_972938.1. NC_002967.9.

3D structure databases

ProteinModelPortaliQ73K81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243275.TDE2339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS12857; AAS12857; TDE_2339.
GeneIDi2739434.
KEGGitde:TDE2339.
PATRICi20526750. VBITreDen445_2207.

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-2381-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiSYL_TREDE
AccessioniPrimary (citable) accession number: Q73K81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.