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Q73K81

- SYL_TREDE

UniProt

Q73K81 - SYL_TREDE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-2381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:TDE_2339
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Leucine--tRNA ligasePRO_0000152108Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243275.TDE2339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ73K81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5412"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q73K81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYPFSTIEP KWQKYWEENK TFKTVEDKNY PKDKRLYILD MFPYPSGDGL    50
    HVGHPEGYTA TDIYSRFLRM SGYNVLHPMG FDSFGLPAEN YAIKTGIHPL 100
    ITTRKNMETF RKQIKSIGLS YDWDREISTS EESYYKWTQW IFLQLFKKGL 150
    AYEKEAPINW CPSCLTGLAN EEVKDGKCER CGAQIQRKNL RQWILKITEY 200
    AERLLEDLDE LDWPESIKIM QKNWIGKSTG AEVDFALVDK DGKETGQKIK 250
    VYTTRPDTIF GATYMVLAPE HELVKSITTS NQEKAVAAYI EEAAKKSDLE 300
    RTDLAKNKTG VFTGAYAINP LTEQKIPVWI SDYILISYGT GAIMAVPAHD 350
    ERDFEFAAQF NLPKIKVVAG AEEWESGKRD FSEEPKACTT EDGYSVNSKQ 400
    FDGLKTEEAK TKITEHLENL GIAKRAVNYK LRDWIFSRQR YWGEPIPLVH 450
    CPSCGIVPLN EHDLPLTLPQ VESYAPTGTG ESPLAAIDSW VNTKCPKCGK 500
    EAKRETNTMP QWAGSCWYYL RFIDPHNNEA FADKEKCDYW MPVDLYVGGT 550
    EHAVLHLLYA RFWHKVLYDL GLVSTKEPFT RLINQGMITS FAYMRKNKSL 600
    VPVDKVKKIS ETEFEDIETG EKLEQVIAKM SKSLKNVINP DDIIKEYGAD 650
    TLRLYEMFLG PLEVSKPWNT SGIMGVFRFL EKIWNLSDRE IYKTPVNDTS 700
    TPETKTLTVL LNKTIKKVTE DTASLNFNTA ISQMMIFINE VSKHKKIPHY 750
    VWYNFVKLLN PYAPHLAEEL WQKMGNDESI AYSHWPMFVE KFCVDQTCTV 800
    VVQVNGKLRG KFEAEAGTSK EELERLALSN EGAIRNIEGK EIKKIITVPD 850
    KLVNIVVQ 858
    Length:858
    Mass (Da):98,404
    Last modified:July 5, 2004 - v1
    Checksum:i087F7974B04C5837
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12857.1.
    RefSeqiNP_972938.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS12857; AAS12857; TDE_2339.
    GeneIDi2739434.
    KEGGitde:TDE2339.
    PATRICi20526750. VBITreDen445_2207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12857.1 .
    RefSeqi NP_972938.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali Q73K81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE2339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS12857 ; AAS12857 ; TDE_2339 .
    GeneIDi 2739434.
    KEGGi tde:TDE2339.
    PATRICi 20526750. VBITreDen445_2207.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TDEN243275:GJ7G-2381-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiSYL_TREDE
    AccessioniPrimary (citable) accession number: Q73K81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3