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Q73K81 (SYL_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:TDE_2339
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152108

Regions

Motif43 – 5412"HIGH" region HAMAP-Rule MF_00049
Motif629 – 6335"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q73K81 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 087F7974B04C5837

FASTA85898,404
        10         20         30         40         50         60 
MAYPFSTIEP KWQKYWEENK TFKTVEDKNY PKDKRLYILD MFPYPSGDGL HVGHPEGYTA 

        70         80         90        100        110        120 
TDIYSRFLRM SGYNVLHPMG FDSFGLPAEN YAIKTGIHPL ITTRKNMETF RKQIKSIGLS 

       130        140        150        160        170        180 
YDWDREISTS EESYYKWTQW IFLQLFKKGL AYEKEAPINW CPSCLTGLAN EEVKDGKCER 

       190        200        210        220        230        240 
CGAQIQRKNL RQWILKITEY AERLLEDLDE LDWPESIKIM QKNWIGKSTG AEVDFALVDK 

       250        260        270        280        290        300 
DGKETGQKIK VYTTRPDTIF GATYMVLAPE HELVKSITTS NQEKAVAAYI EEAAKKSDLE 

       310        320        330        340        350        360 
RTDLAKNKTG VFTGAYAINP LTEQKIPVWI SDYILISYGT GAIMAVPAHD ERDFEFAAQF 

       370        380        390        400        410        420 
NLPKIKVVAG AEEWESGKRD FSEEPKACTT EDGYSVNSKQ FDGLKTEEAK TKITEHLENL 

       430        440        450        460        470        480 
GIAKRAVNYK LRDWIFSRQR YWGEPIPLVH CPSCGIVPLN EHDLPLTLPQ VESYAPTGTG 

       490        500        510        520        530        540 
ESPLAAIDSW VNTKCPKCGK EAKRETNTMP QWAGSCWYYL RFIDPHNNEA FADKEKCDYW 

       550        560        570        580        590        600 
MPVDLYVGGT EHAVLHLLYA RFWHKVLYDL GLVSTKEPFT RLINQGMITS FAYMRKNKSL 

       610        620        630        640        650        660 
VPVDKVKKIS ETEFEDIETG EKLEQVIAKM SKSLKNVINP DDIIKEYGAD TLRLYEMFLG 

       670        680        690        700        710        720 
PLEVSKPWNT SGIMGVFRFL EKIWNLSDRE IYKTPVNDTS TPETKTLTVL LNKTIKKVTE 

       730        740        750        760        770        780 
DTASLNFNTA ISQMMIFINE VSKHKKIPHY VWYNFVKLLN PYAPHLAEEL WQKMGNDESI 

       790        800        810        820        830        840 
AYSHWPMFVE KFCVDQTCTV VVQVNGKLRG KFEAEAGTSK EELERLALSN EGAIRNIEGK 

       850 
EIKKIITVPD KLVNIVVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS12857.1.
RefSeqNP_972938.1. NC_002967.9.

3D structure databases

ProteinModelPortalQ73K81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE2339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS12857; AAS12857; TDE_2339.
GeneID2739434.
KEGGtde:TDE2339.
PATRIC20526750. VBITreDen445_2207.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAVNIVTND.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-2381-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_TREDE
AccessionPrimary (citable) accession number: Q73K81
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries