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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei356Proton donorUniRule annotation1
Active sitei387UniRule annotation1
Active sitei502UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTDEN243275:G1G0Q-2618-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:TDE_2573
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807601 – 525Glucose-6-phosphate isomeraseAdd BLAST525

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE2573

Structurei

3D structure databases

ProteinModelPortaliQ73K18
SMRiQ73K18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q73K18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWKNLDKCT SFTQLQKAHK EQAENLKLAD IFDTENSVKR VKNYSVKMGG
60 70 80 90 100
NLKYNYAAKP VNDEILKALQ SLADEQKLIE KYELLLNGDF INTGENRMVL
110 120 130 140 150
HQLTRGQLKN DVVYKGVNMR SFYLNELKKI KEFSEAVHSG KIKTSQGKVF
160 170 180 190 200
TDVVQIGIGG SDLGPRAMYI ALKNRAKKKM RAHFISNVDP DDAAEVLNSI
210 220 230 240 250
NLASTLFILV SKSGTTQETL ANERFVKSVL EKNGLDCKKQ MLAVTSETSP
260 270 280 290 300
LANNPDYLTS FYMDDFIGGR YSSTSVCGAA VLALAFGMET VEAFLKGAAE
310 320 330 340 350
GDKLSLNKNI KENASLLDAL LGVYERNILG CSATAILPYS QALSRFPAHL
360 370 380 390 400
QQLDMESNGK TVNRFGEKVS YKTGPVIFGE PGTNGQHSFY QLLHQGSDII
410 420 430 440 450
PLQFIGFKKS QIGLDIESEG STNMQKLNAN LAAQIMAFAA GKTDENKNKD
460 470 480 490 500
FAGNRPASLI YGEELNPENL GALLAHYENK VMFQGFIWNL NSFDQEGVQL
510 520
GKTLAKKVLS NDMPPALKAF SEFLL
Length:525
Mass (Da):58,030
Last modified:July 5, 2004 - v1
Checksum:i57A70CF75C24C579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA Translation: AAS13090.1
RefSeqiNP_973171.1, NC_002967.9
WP_002680556.1, NC_002967.9

Genome annotation databases

EnsemblBacteriaiAAS13090; AAS13090; TDE_2573
GeneIDi2739938
KEGGitde:TDE2573
PATRICifig|243275.7.peg.2432

Similar proteinsi

Entry informationi

Entry nameiG6PI_TREDE
AccessioniPrimary (citable) accession number: Q73K18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health